Saraswat B, Visen P K, Patnaik G K, Dhawan B N
ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Reserach Institute, Lucknow, India.
Indian J Exp Biol. 1997 Dec;35(12):1302-5.
Picroliv, the active constituent of P. kurrooa, showed a dose dependent (1.5-12 mg/kg, po for 7 days) hepatoprotective activity against oxytetracycline induced hepatic damage in rat. It increased the number of viable hepatocytes (ex-vivo) significantly. Increase in bile volume and its contents in conscious rat suggests potent anticholestatic property. Picroliv also antagonised alterations in enzyme levels (GOT, GPT, and alkaline phosphatase) in isolated hepatocytes and serum, induced by oxytetracycline (200 mg/kg, i.p.) feeding. Picroliv was more potent than silymarin a known hepatoprotective drug.
胡黄连苷（Picroliv）是胡黄连（P. kurrooa）的活性成分，对土霉素诱导的大鼠肝损伤具有剂量依赖性（1.5 - 12 mg/kg，口服，持续7天）的保肝活性。它显著增加了（体外）存活肝细胞的数量。清醒大鼠胆汁量及其成分的增加表明其具有强大的抗胆汁淤积特性。胡黄连苷还拮抗了土霉素（200 mg/kg，腹腔注射）喂养诱导的离体肝细胞和血清中酶水平（谷草转氨酶、谷丙转氨酶和碱性磷酸酶）的变化。胡黄连苷比已知的保肝药物水飞蓟素更有效。
