Bubber P, Singh K P, Arora S, Bansal D D
Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Exp Biol. 1998 May;36(5):514-6.
Growth hormone deficiency (GHD) is associated as a risk factor in increased mortality from cardiovascular diseases. Abnormal lipid profile and increased levels of plasminogen activator inhibitor (PAI) and fibrinogen have been noted in GHD patients. Present study was carried out to investigate the effect of growth hormone (GH) on plasminogen activator (PA) activity in heart, levels of PA, PAI, glucose and fibrinogen in plasma and serum lipid profile. Rats were injected 125 mU GH kg-1 body weight subcutaneously daily for one week. PA activity was significantly higher in the heart of GH treated rats as compared to controls. GH treatment decreased plasma glucose and fibrinogen levels significantly. No significant differences were seen in PA, PAI in plasma, triglycerides and total cholesterol in serum of the two groups of rats. A significant increase in high density lipoprotein cholesterol (HDL) occurred in GH treated group resulting into a decrease in LDL/HDL ratio. The results indicate that GH may be beneficial in cardiovascular diseases as it decreases the levels of plasma fibrinogen and increases the level of HDL in blood and also increases the level of PA in heart.
生长激素缺乏症（GHD）是心血管疾病死亡率增加的一个风险因素。在GHD患者中已发现血脂异常以及纤溶酶原激活物抑制剂（PAI）和纤维蛋白原水平升高。本研究旨在探讨生长激素（GH）对心脏中纤溶酶原激活物（PA）活性、血浆中PA、PAI、葡萄糖和纤维蛋白原水平以及血清脂质谱的影响。大鼠每天皮下注射125 mU GH/kg体重，持续一周。与对照组相比，GH治疗组大鼠心脏中的PA活性显著更高。GH治疗显著降低了血浆葡萄糖和纤维蛋白原水平。两组大鼠血浆中的PA、PAI、血清中的甘油三酯和总胆固醇未见显著差异。GH治疗组的高密度脂蛋白胆固醇（HDL）显著增加，导致低密度脂蛋白/高密度脂蛋白比值降低。结果表明，GH可能对心血管疾病有益，因为它可降低血浆纤维蛋白原水平，增加血液中HDL水平，并提高心脏中PA的水平。
