Chang M, Saito H, Abe K
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Japan.
Jpn J Pharmacol. 1998 Jul;77(3):251-5. doi: 10.1254/jjp.77.251.
We investigated the effects of histamine H3-receptor ligands on hippocampal synaptic transmission by using anesthetized rats in vivo. The medial perforant path was stimulated, and the population excitatory postsynaptic potential (pEPSP) and population spike were recorded from the granule cell layer of the dentate gyrus. Intracerebroventricular injection of the H3-receptor agonist (R)-alpha-methylhistamine decreased both the pEPSP and population spike, while H3-receptor antagonists, clobenpropit and thioperamide, increased both the pEPSP and population spike. These results suggest that the histaminergic system plays a role in inhibition of hippocampal synaptic excitation via the H3 receptor.
我们通过使用麻醉的大鼠在体内研究了组胺H3受体配体对海马突触传递的影响。刺激内侧穿通通路，并从齿状回颗粒细胞层记录群体兴奋性突触后电位（pEPSP）和群体峰电位。脑室内注射H3受体激动剂（R）-α-甲基组胺可降低pEPSP和群体峰电位，而H3受体拮抗剂氯苯丙醇胺和硫代酰胺则可增加pEPSP和群体峰电位。这些结果表明，组胺能系统通过H3受体在抑制海马突触兴奋中发挥作用。
