Cott J M, Fugh-Berman A
Adult Psychopharmacology Program, National Institute of Mental Health, Rockville, Maryland 20857, USA.
J Nerv Ment Dis. 1998 Aug;186(8):500-1. doi: 10.1097/00005053-199808000-00008.
SJW is a remarkably safe antidepressant with an apparently unique mode of action. Although it has demonstrated efficacy in mild and moderate depression when compared with placebo or tricyclic antidepressants, several research areas beg to be explored. Its effects should be compared with serotonin reuptake inhibitors. Studies in severely depressed patients are lacking, as are studies on its utility as a therapeutic adjunct to standard antidepressants.
圣约翰草是一种非常安全的抗抑郁药，其作用模式明显独特。尽管与安慰剂或三环类抗抑郁药相比，它已在轻度和中度抑郁症中显示出疗效，但仍有几个研究领域有待探索。应将其效果与5-羟色胺再摄取抑制剂进行比较。目前缺乏针对重度抑郁症患者的研究，也缺乏关于其作为标准抗抑郁药治疗辅助药物效用的研究。
