可减少腹膜粘连形成的聚合物。
Polymers that reduce intraperitoneal adhesion formation.
作者信息
Falk K, Holmdahl L, Halvarsson M, Larsson K, Lindman B, Bengmark S
机构信息
Department of Surgery, Ostra Hospital, University of Göteborg, Sweden.
出版信息
Br J Surg. 1998 Aug;85(8):1153-6. doi: 10.1046/j.1365-2168.1998.00784.x.
BACKGROUND
Viscous macromolecules and phospholipids have been shown to reduce postoperative adhesion formation. The ideal agent, or combination of agents, still remains to be identified.
METHODS
The effect of hydrophobically modified ethyl (hydroxyethyl) cellulose (HM-EHEC) and polyquarternium-24 (LM-200), two cellulose-derived polymers, and of sphingomyelin, was examined in an animal model. Adhesions were induced in the parietal peritoneum in a standardized manner and quantity, and the morphology of adhesion formation was evaluated after 7 days.
RESULTS
A significant reduction in adhesion formation was seen in animals receiving LM-200 (P=0.013) and HM-EHEC (P=0.012) as a short-term treatment compared with controls given saline, but not in animals receiving sphingomyelin (P=0.733). Additional effects were seen in the animals receiving LM-200 as a prolonged treatment (P< 0.001) compared with controls. There was no difference in the magnitude of the inflammatory response between the groups.
CONCLUSION
These results suggest that hydrophobically modified polymers are efficient in reducing adhesions, without affecting the inflammatory response.
背景
粘性大分子和磷脂已被证明可减少术后粘连形成。理想的药物或药物组合仍有待确定。
方法
在动物模型中研究了两种纤维素衍生聚合物——疏水改性乙基（羟乙基）纤维素（HM-EHEC）和聚季铵盐-24（LM-200）以及鞘磷脂的作用。以标准化的方式和数量在壁腹膜中诱导粘连，并在7天后评估粘连形成的形态。
结果
与给予生理盐水的对照组相比，接受LM-200（P=0.013）和HM-EHEC（P=0.012）短期治疗的动物粘连形成明显减少，但接受鞘磷脂的动物则没有（P=0.733）。与对照组相比，接受LM-200长期治疗的动物有额外的效果（P<0.001）。各组之间炎症反应的程度没有差异。
结论
这些结果表明，疏水改性聚合物在减少粘连方面有效，且不影响炎症反应。
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