Toth L A, Rehg J E
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Life Sci. 1998;63(8):701-9. doi: 10.1016/s0024-3205(98)00321-x.
Many stressors have well-documented effects on host immune competence. However, two important stressors that have not been extensively characterized in terms of their immune-modulatory properties are sleep deprivation and alterations in light:dark cycles. We therefore evaluated the effects of these stressors on the immune and inflammatory responses of mice inoculated intranasally with influenza virus. In contrast to a previous report, sleep deprivation did not significantly alter viral clearance or antibody titers of either virus-naive or immunized mice. Exposure to constant light also failed to affect these variables. However, repeated overnight restraint, a well-characterized stressor, reduced the pulmonary inflammatory response elicited by influenza virus, as previously reported. The data indicate that sleep deprivation and altered light cycles do not markedly influence selected host defense responses to influenza infection under the conditions tested.
许多应激源对宿主免疫能力的影响已有充分记载。然而，睡眠剥夺和昼夜光照周期改变这两个重要应激源，在免疫调节特性方面尚未得到广泛研究。因此，我们评估了这些应激源对经鼻接种流感病毒的小鼠免疫和炎症反应的影响。与之前的一份报告不同，睡眠剥夺并未显著改变未感染病毒或已免疫小鼠的病毒清除率或抗体滴度。持续光照暴露也未影响这些变量。然而，如先前报道的那样，反复进行过夜束缚（一种特征明确的应激源）可减轻流感病毒引发的肺部炎症反应。数据表明，在测试条件下，睡眠剥夺和光照周期改变不会显著影响宿主对流感感染的特定防御反应。
