Hermann G, Tovar C A, Beck F M, Allen C, Sheridan J F
Department of Medical Microbiology and Immunology, College of Medicine, Ohio State University, Columbus.
J Neuroimmunol. 1993 Aug;47(1):83-94. doi: 10.1016/0165-5728(93)90287-9.
Genetic variation in the response to stress may play a critical role in susceptibility to inflammatory diseases and development of the immune response. Experimental influenza viral infection was used to study the effects of restraint stress (RST) on pathogenesis and development of the immune response. Three inbred strains of mice (C57BL/6, DBA/2, and C3H/HeN) were infected with influenza A/PR8 and subjected to repetitive cycles of RST during development of the immune response. RST diminished cellular immune and inflammatory responses in all three strains; yet only the DBA/2 strain demonstrated RST-associated reduction in influenza viral-induced mortality.
应激反应中的基因变异可能在炎症性疾病易感性和免疫反应发展中起关键作用。采用实验性流感病毒感染来研究束缚应激（RST）对发病机制和免疫反应发展的影响。三种近交系小鼠（C57BL/6、DBA/2和C3H/HeN）感染甲型/PR8流感病毒，并在免疫反应发展过程中经历重复的RST周期。RST降低了所有三个品系的细胞免疫和炎症反应；然而，只有DBA/2品系显示出与RST相关的流感病毒诱导死亡率降低。
