Ramos C, Sánchez G, Pando R H, Baquera J, Hernández D, Mota J, Ramos J, Flores A, Llausás E
Depto. de Arbovirus, Centro de Investigaciones sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.
J Neurovirol. 1998 Aug;4(4):465-8. doi: 10.3109/13550289809114548.
Neurologic complications associated with dengue fever are in general unusual. However, recent reports evidence more frequent neurologic alterations. In Mexico, neurologic involvement has not been reported in dengue cases. This report demonstrates the detection of dengue virus in the brain of a fatal case of dengue hemorrhagic fever. Serotype 4 was detected by immunohistochemistry and by RT-PCR in the inferior olivary nucleus of medulla and in the granular layer of cerebellum. Immunoreactivity was observed in neurons, astrocytes, microglia and endothelial cells. Our results emphasize the importance of neurologic manifestations in patients with dengue fever.
登革热相关的神经系统并发症总体上并不常见。然而，最近的报告表明神经系统改变更为频繁。在墨西哥，登革热病例中尚未有神经系统受累的报告。本报告展示了在一例登革出血热死亡病例的大脑中检测到登革病毒。通过免疫组织化学和逆转录聚合酶链反应（RT-PCR）在延髓下橄榄核和小脑颗粒层中检测到4型血清型。在神经元、星形胶质细胞、小胶质细胞和内皮细胞中观察到免疫反应性。我们的结果强调了登革热患者神经系统表现的重要性。
