Hommel D, Talarmin A, Deubel V, Reynes J M, Drouet M T, Sarthou J L, Hulin A
Intensive Care Unit, General Hospital, Cayenne, French Guiana.
Res Virol. 1998 Jul-Aug;149(4):235-8. doi: 10.1016/s0923-2516(98)80005-8.
Thousands of cases of dengue fever (DF) and several cases of dengue haemorrhagic fever were recorded in French Guiana during the recent outbreak of dengue-2 virus (1991-1992) and in subsequent years. One case with clinical signs typical of classical DF with neurological complications is reported in this study. The neurological features (encephalitis) appeared during the acute phase, 2 days after the onset of fever. Dengue-2 virus was detected in both the cerebrospinal fluid and blood sample. This case was fatal. This first reported case of classical DF with encephalitis in French Guiana is a new demonstration of the potential neurovirulence of dengue viruses.
