Schnitzler C M, Mesquita J
Department of Orthopaedic Surgery, University of the Witwatersrand, Johannesburg, South Africa.
J Bone Miner Res. 1998 Aug;13(8):1300-7. doi: 10.1359/jbmr.1998.13.8.1300.
We examined the relationship between bone histomorphometric variables versus marrow cellularity, marrow adiposity (among hemopoietic cells), and fatty degeneration (areas of only fat) of bone marrow in iliac crest bone samples from 98 normal black (n = 53) and white (n = 45) males and females. We found blacks to have greater marrow cellularity (p = 0.0001), less marrow adiposity (among hemopoietic cells, p = 0.0001), greater values for bone volume (p = 0.030), trabecular thickness (p = 0.002), and static bone turnover variables (osteoid volume, p = 0.001; osteoid surface, p = 0.001; osteoid thickness, p = 0.001; eroded surface, p = 0.0006) than whites. Marrow cellularity correlated positively with static bone turnover variables osteoid volume (r = 0.257, p = 0.011), osteoid surface (r = 0.265, p = 0.008), osteoid thickness (r = 0.217, p = 0.032), and eroded surface (r = 0.273, p = 0.007) when all 98 cases were analyzed together. These findings suggest that marrow cells may influence bone turnover. The extent of fatty degeneration, but not that of adipose tissue, increased with age in blacks (r = 0.476, p = 0.0003) and whites (r = 0.476, p = 0.001), as did bone loss. There was no racial difference in the extent of fatty degeneration. We conclude that the lesser extent of adiposity in blacks is a racial characteristic that is unaffected by aging, whereas fatty degeneration which may have partly occupied space vacated by bone loss, is an aging phenomenon, unrelated to race. Greater bone turnover in blacks may be expected to lead to more frequent renewal of fatigue-damaged bone, which together with sturdier bone structure may contribute to the lower fragility fracture rates in blacks.
我们研究了98名正常黑人（n = 53）和白人（n = 45）男性及女性髂嵴骨样本中骨组织形态计量学变量与骨髓细胞密度、骨髓脂肪含量（造血细胞中的）以及骨髓脂肪变性（仅脂肪区域）之间的关系。我们发现黑人的骨髓细胞密度更高（p = 0.0001），骨髓脂肪含量更低（造血细胞中的，p = 0.0001），骨体积（p = 0.030）、小梁厚度（p = 0.002）以及静态骨转换变量（类骨质体积，p = 0.001；类骨质表面，p = 0.001；类骨质厚度，p = 0.001；侵蚀表面，p = 0.0006）的值均高于白人。当对所有98例病例进行综合分析时，骨髓细胞密度与静态骨转换变量类骨质体积（r = 0.257，p = 0.011）、类骨质表面（r = 0.265，p = 0.008）、类骨质厚度（r = 0.217，p = 0.032）以及侵蚀表面（r = 0.273，p = 0.007）呈正相关。这些发现表明骨髓细胞可能影响骨转换。黑人（r = 0.476，p = 0.0003）和白人（r = 0.476，p = 0.001）中，脂肪变性的程度而非脂肪组织的程度随年龄增加，骨量丢失情况也是如此。脂肪变性程度不存在种族差异。我们得出结论，黑人中较低的脂肪含量是一种不受衰老影响的种族特征，而可能部分占据了因骨量丢失而空出空间的脂肪变性是一种衰老现象，与种族无关。黑人中更高的骨转换可能会导致疲劳损伤的骨骼更频繁更新，这与更坚固的骨骼结构一起可能导致黑人中较低的脆性骨折发生率。
