Kaczmarski E B, Ragunathan P L, Marsh J, Gray S J, Guiver M
PHLS Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital.
Commun Dis Public Health. 1998 Mar;1(1):54-6.
The widening gap observed between numbers of culture confirmed and notified cases of meningococcal infection has driven the development of non-culture based polymerase chain reactions (PCRs) to enhance the detection of meningococcal disease. The development of a national PCR-based service increased the number of laboratory confirmed cases of meningococcal disease by 35% in the first year. Advancing technology in the laboratory is reducing in-lab processing time.
在脑膜炎球菌感染的培养确诊病例数和通报病例数之间观察到的差距不断扩大,推动了基于非培养的聚合酶链反应(PCR)技术的发展,以加强对脑膜炎球菌病的检测。基于PCR的全国性检测服务开展的第一年,实验室确诊的脑膜炎球菌病病例数增加了35%。实验室技术的进步正在缩短实验室检测时间。