Das B K, Ramesh J, Agarwal J K, Mishra O P, Bhatt R P
Department of Pediatrics, Banaras Hindu University, Varanasi, India.
J Trop Pediatr. 1998 Aug;44(4):230-1. doi: 10.1093/tropej/44.4.230.
Fifteen children with protein-energy malnutrition and eight healthy children between the ages of 6 months and 60 months were studied for blood glucose and serum insulin levels in the fasting state and 120 minutes following oral glucose load. The measurements were repeated after normalization of the body weight following 6 weeks of nutritional rehabilitation. The fasting blood glucose increased significantly in the post-treatment period and became comparable to the control value. The abnormal blood glucose response to oral glucose load also normalized. The serum insulin level rose significantly (p < 0.001) in the post-treatment period but failed to normalize. The response to oral glucose load was similar. The observed lower insulin response, despite normoglycemia, after 6 weeks of nutritional rehabilitation indicates persistence of hormonal imbalance which may need a longer duration of rehabilitation for full recovery.
对15名患有蛋白质 - 能量营养不良的儿童和8名年龄在6个月至60个月之间的健康儿童进行了研究，测量他们在空腹状态以及口服葡萄糖负荷后120分钟时的血糖和血清胰岛素水平。在经过6周的营养康复使体重恢复正常后，重复进行这些测量。治疗后空腹血糖显著升高，且与对照值相当。口服葡萄糖负荷后异常的血糖反应也恢复正常。治疗后血清胰岛素水平显著升高（p < 0.001），但未恢复正常。对口服葡萄糖负荷的反应相似。营养康复6周后，尽管血糖正常，但观察到较低的胰岛素反应，这表明激素失衡持续存在，可能需要更长时间的康复才能完全恢复。
