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蛋白质-热量营养不良时的早期胰岛素释放及其对补钾的反应。

Early insulin release and its response to potassium supplementation in protein-calorie malnutrition.

作者信息

Becker D J, Mann M D, Weinkove E, Pimstone B L

出版信息

Diabetologia. 1975 Jun;11(3):237-9. doi: 10.1007/BF00422328.

DOI:10.1007/BF00422328
PMID:807496
Abstract

Early insulin release after oral glucose is absent in protein-calorie malnutrition (PCM). There is an increase of the insulin-glucose ratio at 10 and 15 min induced by potassium supplementation compared to a similar group receiving an identical diet without supplementary potassium. This suggests that impaired insulin secretion in PMC is in part due to a potassium mediated disturbance of insulin release.

摘要

蛋白质 - 热量营养不良（PCM）患者口服葡萄糖后早期胰岛素释放缺失。与接受相同饮食但未补充钾的类似组相比，补充钾后10分钟和15分钟时胰岛素 - 葡萄糖比值升高。这表明PCM中胰岛素分泌受损部分是由于钾介导的胰岛素释放紊乱所致。

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本文引用的文献

1
Electrolyte and nitrogen metabolism in kwashiorkor.夸希奥科病中的电解质和氮代谢
S Afr J Lab Clin Med. 1956 Sep;2(3):206-31.
2
Effect of pulse administration of glucose or glucagon on insulin secretion in vitro.脉冲式给予葡萄糖或胰高血糖素对体外胰岛素分泌的影响。
Metabolism. 1967 Mar;16(3):222-33. doi: 10.1016/0026-0495(67)90171-0.
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Cation requirements for insulin secretion in the isolated perfused pancreas.离体灌注胰腺中胰岛素分泌的阳离子需求
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4
Hypertension, the potassium ion and impaired carbohydrate tolerance.高血压、钾离子与糖耐量受损。
N Engl J Med. 1965 Nov 18;273(21):1135-43. doi: 10.1056/NEJM196511182732106.
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The carbohydrate metabolism of normal subjects during potassium depletion.钾缺乏时正常受试者的碳水化合物代谢。
Diabetologia. 1971 Apr;7(2):82-6. doi: 10.1007/BF00443886.
6
Insulin secretion in protein-calorie malnutrition. I. Quantitative abnormalities and response to treatment.蛋白质 - 热量营养不良时的胰岛素分泌。I. 定量异常及对治疗的反应。
Diabetes. 1971 Aug;20(8):542-51. doi: 10.2337/diab.20.8.542.
7
Insulin responses to glucose: evidence for a two pool system in man.胰岛素对葡萄糖的反应：人体中双池系统的证据。
J Clin Invest. 1969 Dec;48(12):2309-19. doi: 10.1172/JCI106197.
8
The mechanism of insulin secretion after oral glucose administration. I. Multiphasic course of insulin mobilization after oral administration of glucose in conscious dogs. Differences to the behaviour after intravenous administration.口服葡萄糖后胰岛素分泌的机制。I. 清醒犬口服葡萄糖后胰岛素动员的多相过程。与静脉注射后行为的差异。
Diabetologia. 1972 Apr;8(2):104-10. doi: 10.1007/BF01235634.
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Human insulin secretion: as integrated approach.
Annu Rev Med. 1970;21:219-40. doi: 10.1146/annurev.me.21.020170.001251.
10
Dynamics of insulin secretion by the perfused rat pancreas.灌注大鼠胰腺胰岛素分泌的动力学
Endocrinology. 1968 Sep;83(3):572-84. doi: 10.1210/endo-83-3-572.