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虫媒病毒蚀斑形成过程中的可扩散病毒干扰

Diffusible viral interference during arbovirus plaque formation.

作者信息

Stanton G J

出版信息

Infect Immun. 1976 Jun;13(6):1771-2. doi: 10.1128/iai.13.6.1771-1772.1976.

DOI:10.1128/iai.13.6.1771-1772.1976
PMID:971948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC420830/
Abstract

A radially diffusing zone of nonspecific interference was observed surrounding plaques of Western equine encephalitis virus. The increase in diameters of the zones of interference were linear and more rapid than increases in plaque diameters. These observations raise the possibility that viral-induced interference could account for the diminished growth of Western equine encephalitis virus plaques with time or even the initial formation of plaques. In addition, this system could be used as a model to study localized host defenses during early infection of solid tissues in vivo.

摘要

在西部马脑炎病毒蚀斑周围观察到一个呈放射状扩散的非特异性干扰区。干扰区直径的增加呈线性，且比蚀斑直径的增加更为迅速。这些观察结果提示，病毒诱导的干扰可能是西部马脑炎病毒蚀斑随时间增长减弱甚至蚀斑最初形成的原因。此外，该系统可作为一个模型，用于研究体内实体组织早期感染期间的局部宿主防御。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4ee/420830/8d98346ce9de/iai00222-0242-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4ee/420830/8d98346ce9de/iai00222-0242-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4ee/420830/8d98346ce9de/iai00222-0242-a.jpg

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本文引用的文献

1
Enhanced detection of Western equine encephalitis virus plaque variants in crowded cultures and plaque progeny--potential use in genetic studies.在密集培养物和空斑后代中增强对西部马脑炎病毒空斑变体的检测——在遗传学研究中的潜在用途。
Appl Microbiol. 1974 Jul;28(1):145-50. doi: 10.1128/am.28.1.145-150.1974.
2
Inhibition of chickenpox lesions by measles and measles rash by chickenpox.麻疹抑制水痘皮损，水痘抑制麻疹皮疹。
JAMA. 1973 Mar 5;223(10):1154-5. doi: 10.1001/jama.1973.03220100048013.