The modified DNA base beta-D-glucosyl-hydroxymethyluracil is not found in the tsetse fly stages of Trypanosoma brucei.

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作者信息

van Leeuwen F, Dirks-Mulder A, Dirks R W, Borst P, Gibson W

机构信息

Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam.

出版信息

Mol Biochem Parasitol. 1998 Jul 1;94(1):127-30. doi: 10.1016/s0166-6851(98)00060-7.

DOI:10.1016/s0166-6851(98)00060-7

PMID:9719516

Abstract

摘要

相似文献

The modified DNA base beta-D-glucosyl-hydroxymethyluracil is not found in the tsetse fly stages of Trypanosoma brucei.

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beta-D-glucosyl-hydroxymethyluracil: a novel modified base present in the DNA of the parasitic protozoan T. brucei.β-D-葡萄糖基羟甲基尿嘧啶：一种存在于寄生原生动物布氏锥虫DNA中的新型修饰碱基。

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beta-D-glucosyl-hydroxymethyluracil, a novel base in African trypanosomes and other Kinetoplastida.β-D-葡萄糖基羟甲基尿嘧啶，一种在非洲锥虫和其他动基体目生物中的新型碱基。

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Tandemly repeated DNA is a target for the partial replacement of thymine by beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.串联重复DNA是布氏锥虫中β-D-葡糖基羟甲基尿嘧啶部分取代胸腺嘧啶的靶点。

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Quantitative mass spectrometry-based analysis of β-D-glucosyl-5-hydroxymethyluracil in genomic DNA of Trypanosoma brucei.基于定量质谱法分析布氏锥虫基因组DNA中的β-D-葡萄糖基-5-羟甲基尿嘧啶。

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The telomeric GGGTTA repeats of Trypanosoma brucei contain the hypermodified base J in both strands.布氏锥虫的端粒GGGTTA重复序列在两条链中都含有高度修饰的碱基J。

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beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres.β-D-葡糖基羟甲基尿嘧啶是动质体原生动物中一种保守的DNA修饰，在其端粒中含量丰富。

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2366-71. doi: 10.1073/pnas.95.5.2366.

A base called J.一种名为J的碱基。

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Tsetse fly tolerance to T. brucei infection: transcriptome analysis of trypanosome-associated changes in the tsetse fly salivary gland.采采蝇对布氏锥虫感染的耐受性：采采蝇唾液腺中锥虫相关变化的转录组分析

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Tetracycline induction of gene expression in Trypanosoma brucei within the tsetse fly vector.采采蝇载体中布氏锥虫基因表达的四环素诱导

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JBP1 and JBP2 proteins are Fe2+/2-oxoglutarate-dependent dioxygenases regulating hydroxylation of thymidine residues in trypanosome DNA.JBP1 和 JBP2 蛋白是依赖 Fe2+/2-氧代戊二酸的双加氧酶，可调节原生动物 DNA 中胸苷残基的羟化。

J Biol Chem. 2012 Jun 8;287(24):19886-95. doi: 10.1074/jbc.M112.341974. Epub 2012 Apr 18.

Chromatin modifications, epigenetics, and how protozoan parasites regulate their lives.染色质修饰、表观遗传学以及原生动物寄生虫如何调节它们的生活。

Trends Parasitol. 2012 May;28(5):202-13. doi: 10.1016/j.pt.2012.02.009. Epub 2012 Apr 3.

The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1.JBP1 中新型 DNA 结合域识别含碱基 J 的 DNA 的结构基础。

Nucleic Acids Res. 2011 Jul;39(13):5715-28. doi: 10.1093/nar/gkr125. Epub 2011 Mar 16.

The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase.锥虫中与DNA碱基J结合的蛋白质具有胸苷羟化酶的特征。

Nucleic Acids Res. 2007;35(7):2107-15. doi: 10.1093/nar/gkm049. Epub 2007 Mar 27.

Trypanosome telomeres are protected by a homologue of mammalian TRF2.锥虫端粒由哺乳动物TRF2的同源物保护。

Mol Cell Biol. 2005 Jun;25(12):5011-21. doi: 10.1128/MCB.25.12.5011-5021.2005.

Base J originally found in kinetoplastida is also a minor constituent of nuclear DNA of Euglena gracilis.最初在动质体中发现的碱基J也是纤细裸藻核DNA的次要成分。

Nucleic Acids Res. 2000 Aug 15;28(16):3017-21. doi: 10.1093/nar/28.16.3017.

Telomere maintenance and length regulation in Trypanosoma brucei.布氏锥虫中的端粒维持与长度调控

EMBO J. 2000 May 15;19(10):2332-9. doi: 10.1093/emboj/19.10.2332.

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