Tortosa Serrano J A, Hernández-Palazón J, Prado Burguete C, Ibarra Berrocal I, Luna Maldonado A, Periago Jiménez J F
Servicio de Anestesiología y Reanimación, Hospital Universitario Virgen de la Arrixaca, Murcia.
Rev Esp Anestesiol Reanim. 1998 Jun-Jul;45(6):214-9.
To measure the level of occupational exposure to isoflurane in the operating room, and to determine the relation between isoflurane concentration in atmospheric and exhaled air.
One hundred seventy-eight samples were obtained from 60 male and female subjects who work in the operating room of our hospital. To monitor workplace exposure we used passive diffusion samplers. Biological monitoring (isoflurane in exhaled air) was accomplished with standard adsorption tubes to collect exhaled air samples. Gases were thermically separated and analyzed by gas chromatography.
Atmospheric isoflurane concentrations ranged between 1.14 and 157.23 mg/m3 (geometric mean 16.23 mg/m3). Exhaled isoflurane concentrations ranged from 0.15 to 26.09 mg/m3 (geometric mean 2.85 mg/m3). Atmospheric and exhaled isoflurane concentrations were strongly related (r = 0.82; p < 0.0001). Linearity was determined by the following equation: log of exhaled isoflurane concentration = -0.69 + 0.95 log of atmospheric isoflurane concentration.
The concentrations of isoflurane in atmospheric and exhaled air found in our study exceed the maximum levels for halogenated gases recommended by the National Institute for Occupational Safety and Health, although they do not exceed the levels stipulated by Swiss authorities. In order to adequately assess operating room antipollution measures, atmospheric and biologic monitoring of isoflurane and other inhaled anesthetic gas concentrations is necessary.
测量手术室中异氟烷的职业暴露水平，并确定大气和呼出气体中异氟烷浓度之间的关系。
从我院手术室工作的60名男性和女性受试者中采集了178个样本。为监测工作场所暴露，我们使用了被动扩散采样器。生物监测（呼出气体中的异氟烷）通过标准吸附管收集呼出气体样本完成。气体经热分离后用气相色谱法分析。
大气中异氟烷浓度范围为1.14至157.23 mg/m³（几何平均值为16.23 mg/m³）。呼出的异氟烷浓度范围为0.15至26.09 mg/m³（几何平均值为2.85 mg/m³）。大气和呼出的异氟烷浓度密切相关（r = 0.82；p < 0.0001）。线性关系由以下方程确定：呼出异氟烷浓度的对数 = -0.69 + 0.95×大气异氟烷浓度的对数。
我们研究中发现的大气和呼出气体中的异氟烷浓度超过了美国国家职业安全与健康研究所推荐的卤化气体最高水平，尽管未超过瑞士当局规定的水平。为了充分评估手术室的防污染措施，有必要对异氟烷和其他吸入麻醉气体浓度进行大气和生物监测。
