Domenegati E, Rolandi L, Lodola L, Bressan M A, Ceriana P, Filisetti P
I Servizio di Anestesia e Rianimazione, IRCCS Policlinico S. Matteo, Pavia.
Minerva Anestesiol. 1996 Sep;62(9):297-305.
To verify the results of a health surveillance protocol for personnel exposed to inhalation anaesthetics.
Yearly follow-up of operating room personnel.
Operating theatres of a university hospital; one "clean" room with waste anaesthetic scavengers, a second older room an thus "dirty", a third room with appropriate technical requirements, but with a considerable environmental emission of anaesthetics.
Twenty-four technical surgical assistants and anaesthesiologists. INTERVENTION OR METHODS: Determination of the number of changes of air by means of concentration decay; determination of the baseline and final value of the environmental anaesthetics by infrared photoacoustic spectroscopy; analysis of the microclimate and inspection of the equipment. Determination of anaesthetics in the urine of personnel at the end of the work shift, using a gas-chromatograph with head space. Yearly medical check-up and blood tests.
In the first year of observation we found values of nitrous oxide in one room and of isoflurane in all three rooms which exceeded the upper limit value. Acceptable values in all the rooms were detected during the second year. The values of anaesthetics found in urine samples reflected those measured in the rooms. Personnel reported subjective symptoms, but no blood alterations related to exposure were found.
The application of the protocol has allow us to estimate the level of pollution and to suggest behavioral rules and technical precautions that have decreased the emission of anaesthetics in the environment. Blood tests are not a valid index of possible damage caused by exposure.
验证针对吸入麻醉剂暴露人员的健康监测方案的结果。
对手术室人员进行年度随访。
一家大学医院的手术室;一间配备废气麻醉清除装置的“清洁”房间,另一间较旧因而“脏污”的房间,第三间满足适当技术要求但麻醉剂环境排放量可观的房间。
24名外科技术助理和麻醉医生。
通过浓度衰减测定换气次数;采用红外光声光谱法测定环境麻醉剂的基线值和最终值;分析微气候并检查设备。使用顶空气相色谱仪在工作班次结束时测定人员尿液中的麻醉剂。进行年度体检和血液检查。
在观察的第一年,我们发现一个房间中的氧化亚氮值以及所有三个房间中的异氟烷值均超过上限值。在第二年检测到所有房间中的值均在可接受范围内。尿液样本中发现的麻醉剂值反映了在房间中测得的值。人员报告了主观症状,但未发现与暴露相关的血液变化。
该方案的应用使我们能够估计污染水平,并提出减少环境中麻醉剂排放的行为规则和技术预防措施。血液检查并非暴露可能造成损害的有效指标。