从达克奥寇梯木中提取的网状番荔枝碱对大鼠和小鼠的中枢抑制作用。

Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice.

作者信息

Morais L C, Barbosa-Filho J M, Almeida R N

机构信息

Laboratório de Tecnologia Farmacêutica e Departamento de Fisiologia e Patologia, Universidade Federal da Paraiba, João Pessoa, Brazil.

出版信息

J Ethnopharmacol. 1998 Aug;62(1):57-61. doi: 10.1016/s0378-8741(98)00044-0.

DOI:10.1016/s0378-8741(98)00044-0

PMID:9720612

Abstract

Neuropharmacological studies were carried out with reticuline, a benzylisoquinoline alkaloid, isolated from Ocotea duckei Vattimo. It was found that reticuline (50-100 mg/kg i.p.) produced alteration of behaviour pattern, prolongation of pentobarbital-induced sleep, reduction in motor coordination and D-amphetamine-induced hypermotility and suppression of the conditioned avoidance response. These observations suggest that reticuline possesses potent central nervous system depressant action.

摘要

对从奥氏奥寇梯木（Ocotea duckei Vattimo）中分离出的苄基异喹啉生物碱网状番荔枝碱进行了神经药理学研究。结果发现，网状番荔枝碱（腹腔注射50 - 100毫克/千克）会导致行为模式改变、戊巴比妥诱导的睡眠时间延长、运动协调性降低、D - 苯丙胺诱导的活动过度受到抑制以及条件性回避反应受到抑制。这些观察结果表明，网状番荔枝碱具有强大的中枢神经系统抑制作用。