山槐叶总生物碱部位的中枢神经系统药理作用
CNS pharmacological effects of the total alkaloidal fraction from Albizia inopinata leaves.
作者信息
Assis T S, Almeida R N, Barbosa-Filho J M, Medeiros I A
机构信息
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Caixa Postal 5009, CEP: 58051-970, João Pessoa, Paraíba, Brazil.
出版信息
Fitoterapia. 2001 Feb;72(2):124-30. doi: 10.1016/s0367-326x(00)00268-9.
The total alkaloidal fraction of Albizia inopinata leaves (FLA) was investigated for its central nervous system (CNS) effects. FLA (10 mg/kg, i.p.) significantly reduced (45%) the locomotor activity in mice. In addition, it inhibited the conditioned avoidance response behavior and induced ptosis in rats. On the other hand, FLA did not exert significant effect on catalepsy, but potentiated the haloperidol-induced catalepsy. No effect was observed on sleep induced by sodium pentobarbital or apomorphine-induced stereotypes.
对山合欢叶总生物碱部分（FLA）的中枢神经系统（CNS）作用进行了研究。腹腔注射FLA（10毫克/千克）可显著降低（45%）小鼠的自发活动。此外，它还能抑制大鼠的条件性回避反应行为并引起眼睑下垂。另一方面，FLA对僵住症没有显著影响，但能增强氟哌啶醇诱导的僵住症。对戊巴比妥钠诱导的睡眠或阿扑吗啡诱导的刻板行为未观察到影响。
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