Reanmongkol W, Matsumoto K, Watanabe H, Subhadhirasakul S, Sakai S
Division of Pharmacology, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Biol Pharm Bull. 1994 Oct;17(10):1345-50. doi: 10.1248/bpb.17.1345.
Effects of crude alkaloids extracted from the stem bark of Hunteria zeylanica Gard. (H. zeylanica) on nociceptive responses, capillary permeability, yeast-induced hyperthermia, pentobarbital-induced sleep, and spontaneous motor activity were investigated. Oral administration of 50 mg/kg H. zeylanica alkaloid extract significantly decreased the number of writhings induced by intraperitoneal acetic acid. The extract at 100-200 mg/kg significantly increased nociceptive threshold of the inflamed but not the non-inflamed paw in the Randall-Selitto test. Moreover, in the formalin test, the extract (100 mg/kg) significantly decreased licking activity in the late phase without affecting the activity in the early phase. However, the extract did not produce antinociceptive effect in the hot plate test, while it inhibited increase of vascular permeability induced by acetic acid in the capillary permeability test. Moreover, the extract dose-dependently reduced yeast-induced hyperthermia in rats without affecting normothermia. It did not affect pentobarbital-induced sleep, but significantly increased locomotor activity at 100 mg/kg. These results suggest that H. zeylanica alkaloid extract possesses antinociceptive and antipyretic effects, and that the former effect may be mediated by its anti-inflammatory action.
研究了从锡兰吊灯花（Hunteria zeylanica Gard.，简称H. zeylanica）茎皮中提取的粗生物碱对伤害性反应、毛细血管通透性、酵母诱导的发热、戊巴比妥诱导的睡眠以及自发运动活动的影响。口服50mg/kg的H. zeylanica生物碱提取物可显著减少腹腔注射醋酸诱导的扭体次数。在Randall-Selitto试验中，100-200mg/kg的提取物可显著提高炎症爪子而非未发炎爪子的伤害性阈值。此外，在福尔马林试验中，提取物（100mg/kg）可显著降低后期的舔舐活动，而不影响早期的活动。然而，该提取物在热板试验中未产生抗伤害性作用，而在毛细血管通透性试验中可抑制醋酸诱导的血管通透性增加。此外，该提取物可剂量依赖性地降低大鼠酵母诱导的发热，而不影响正常体温。它不影响戊巴比妥诱导的睡眠，但在100mg/kg时可显著增加运动活动。这些结果表明，H. zeylanica生物碱提取物具有抗伤害性和解热作用，且前者作用可能由其抗炎作用介导。
