Knutsen T
Cytogenetics Laboratory, Experimental Therapeutics Section Medicine Branch, NCI National Institutes of Health, Bethesda, MD, USA.
Leuk Lymphoma. 1998 Sep;31(1-2):1-19. doi: 10.3109/10428199809057581.
The study of chromosomal changes related to tumor progression in NHL is complicated by the various histologic classification systems and the lack of large serial studies comparing abnormalities at different disease stages. The T-cell lymphomas frequently involve rearrangements of the T-cell receptors and tumor progression is marked by a change from single cell aberrations and polyclonality in low grade disease to monoclonal formation, complex clones, polyploidy, and abnormalities of 1p, 6q, 7, and 13 in high grade T-NHL. In B-cell NHL, specific translocations and oncogene rearrangements are associated with specific NHL subtypes de novo; many of these translocations involve immunoglobulin genes, such as t(14;18) in follicular lymphoma, t(11;14) in MCL, t(3;14) in DLLC, and t(8;14) in Burkitt's lymphoma. Tumor progression is associated with secondary abnormalities which are generally not confined to a particular NHL subtype. Some abnormalities, such as those involving chromosomes 1, 6, and 17, >4-6 clonal markers/cell, and rearrangements of c-MYC and TP53, have prognostic significance while others, such as trisomies 7, 12, 18, and X, are associated with tumor progression but their influence on overall survival is uncertain.
非霍奇金淋巴瘤（NHL）中与肿瘤进展相关的染色体变化研究因各种组织学分类系统以及缺乏比较不同疾病阶段异常情况的大型系列研究而变得复杂。T细胞淋巴瘤经常涉及T细胞受体的重排，肿瘤进展的特点是从低度疾病中的单细胞畸变和多克隆性转变为高度T细胞非霍奇金淋巴瘤中的单克隆形成、复杂克隆、多倍体以及1p、6q、7和13号染色体异常。在B细胞非霍奇金淋巴瘤中，特定的易位和癌基因重排与特定的原发性非霍奇金淋巴瘤亚型相关；其中许多易位涉及免疫球蛋白基因，如滤泡性淋巴瘤中的t(14;18)、套细胞淋巴瘤中的t(11;14)、弥漫性大B细胞淋巴瘤中的t(3;14)以及伯基特淋巴瘤中的t(8;14)。肿瘤进展与继发性异常相关，这些异常通常不限于特定的非霍奇金淋巴瘤亚型。一些异常，如涉及1、6和17号染色体的异常、每个细胞>4 - 6个克隆标志物以及c-MYC和TP53的重排，具有预后意义，而其他异常，如7、12、18号染色体三体和X染色体三体，与肿瘤进展相关，但其对总生存的影响尚不确定。
