Shikano T, Ishikawa Y, Naito H, Kobayashi R, Nakadate H, Hatae Y, Takeda T
Department of Pediatrics, Hokkaido University, Japan.
Cancer. 1992 Aug 1;70(3):714-9. doi: 10.1002/1097-0142(19920801)70:3<714::aid-cncr2820700329>3.0.co;2-z.
Cytogenetic studies were performed successfully on 24 patients with non-Hodgkin lymphoma (NHL) who were younger than 15 years of age. Of these, 22 patients (92%) had abnormal clones. With respect to histologic findings, 3 (25%) of the 12 patients with lymphoblastic lymphoma had 14q11 translocations and 2 (17%) had t(9;17) (q34;q23). Four (80%) of the five patients with small non-cleaved cell lymphoma had t(8;14)(q24;q32). With respect to immunologic findings, four (44%) of the nine patients with T-cell lymphoma had abnormalities consisting of 14q11 and 7q36 translocations, in which the T-cell receptor genes resided. Three (33%) of the patients with T-cell lymphoma had t(9;17)(q34;q23). However, three (43%) of the seven patients with B-cell lymphoma had t(8;14) (q23;q32), and two (29%) of the patients with B-cell lymphoma had an extra i(11q) chromosome with a resultant 11q tetrasomy. Non-T-cell non-B-cell lymphomas, which occurred in 21% of all patients, showed various chromosomal abnormalities. This study demonstrated that, in childhood NHL, karyotype correlates closely with immunophenotype, clinical features, and histologic findings.
对24例年龄小于15岁的非霍奇金淋巴瘤（NHL）患者成功进行了细胞遗传学研究。其中，22例患者（92%）有异常克隆。关于组织学发现，12例淋巴母细胞淋巴瘤患者中有3例（25%）有14q11易位，2例（17%）有t(9;17)(q34;q23)。5例小无裂细胞淋巴瘤患者中有4例（80%）有t(8;14)(q24;q32)。关于免疫学发现，9例T细胞淋巴瘤患者中有4例（44%）有异常，包括14q11和7q36易位，T细胞受体基因位于其中。3例（33%）T细胞淋巴瘤患者有t(9;17)(q34;q23)。然而，7例B细胞淋巴瘤患者中有3例（43%）有t(8;14)(q23;q32)，2例（29%）B细胞淋巴瘤患者有额外的i(11q)染色体，导致11q四体。非T细胞非B细胞淋巴瘤占所有患者的21%，表现出各种染色体异常。这项研究表明，在儿童NHL中，核型与免疫表型、临床特征和组织学发现密切相关。
