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椎间盘中的尿苷二磷酸葡萄糖脱氢酶

Uridine diphosphoglucose dehydrogenase in the intervertebral disc.

作者信息

Butler W F, Pousty I

出版信息

Histochem J. 1976 Sep;8(5):539-42. doi: 10.1007/BF01003843.

DOI:10.1007/BF01003843
PMID:972074
Abstract

Intervertebral discs of an old sheep and a young pig were examined for the presence of cells containing the enzyme uridine diphosphoglucose dehydrogenase. In the sheep, the inner anulus had a higher proportion of active cells than the outer anulus; in the pig, there was no difference. From a consideration of cell numbers, it is suggested that there is an accumulation of glycosaminoglycans in the centre of the disc rather than an increased production rate. Notochordal cells in the pig disc contain uridine diphosphoglucose dehydrogenase and are capable of producing glycosaminoglycans.

摘要

对一只老绵羊和一头幼猪的椎间盘进行检查,以确定是否存在含有尿苷二磷酸葡萄糖脱氢酶的细胞。在绵羊中,内环纤维环的活性细胞比例高于外环纤维环;在猪中,则没有差异。从细胞数量的角度考虑,有人认为椎间盘中央存在糖胺聚糖的积累,而不是生产率的提高。猪椎间盘的脊索细胞含有尿苷二磷酸葡萄糖脱氢酶,并且能够产生糖胺聚糖。

相似文献

1
Uridine diphosphoglucose dehydrogenase in the intervertebral disc.椎间盘中的尿苷二磷酸葡萄糖脱氢酶
Histochem J. 1976 Sep;8(5):539-42. doi: 10.1007/BF01003843.
2
Half-of-the-sites reactivity of bovine liver uridine diphosphoglucose dehydrogenase toward iodoacetate and iodoacetamide.牛肝尿苷二磷酸葡萄糖脱氢酶对碘乙酸盐和碘乙酰胺的半位点反应性
Biochemistry. 1976 Dec 14;15(25):5665-71. doi: 10.1021/bi00670a036.
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[Mechanism of the enzymatic reaction catalyzed by uridine diphosphate glucose dehydrogenase. The chemical synthesis of uridine diphosphate glucose-6-H3 and its oxidation by uridine diphosphate glucose dehydrogenase].[尿苷二磷酸葡萄糖脱氢酶催化的酶促反应机制。尿苷二磷酸葡萄糖-6-H3的化学合成及其被尿苷二磷酸葡萄糖脱氢酶氧化]
Biokhimiia. 1975 Jan-Feb;40(1):123-6.
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Cells from different regions of the intervertebral disc: effect of culture system on matrix expression and cell phenotype.来自椎间盘不同区域的细胞:培养系统对基质表达和细胞表型的影响。
Spine (Phila Pa 1976). 2002 May 15;27(10):1018-28. doi: 10.1097/00007632-200205150-00004.
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Interaction of uridine diphosphate glucose with calf liver uridine diphosphate glucose dehydrogenase. Significance of hydroxyl groups at C-3, C-4 and C-6 of hexosyl residue.尿苷二磷酸葡萄糖与小牛肝尿苷二磷酸葡萄糖脱氢酶的相互作用。己糖基残基C-3、C-4和C-6位羟基的意义。
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Interaction of uridine diphosphate glucose analogs with calf liver uridine diphosphate glucose dehydrogenase. Influence of substituents at C-5 of pyrimidine nucleus.尿苷二磷酸葡萄糖类似物与小牛肝脏尿苷二磷酸葡萄糖脱氢酶的相互作用。嘧啶核C-5位取代基的影响。
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Uridine diphosphoglucose dehydrogenase activity in synovial lining cells in the experimental antigen induced model of rheumatoid arthritis: an indication of synovial lining cell function.实验性抗原诱导类风湿关节炎模型中滑膜衬里细胞的尿苷二磷酸葡萄糖脱氢酶活性:滑膜衬里细胞功能的一个指标
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Mechanism of action of uridine diphosphoglucose dehydrogenase. Evidence for a second reversible dehydrogenation step involving an essential thiol group.
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Effect of D2O on enzyme-substrate interaction in rat liver uridine diphosphoglucose dehydrogenase.重水对大鼠肝脏尿苷二磷酸葡萄糖脱氢酶中酶-底物相互作用的影响。
Indian J Biochem Biophys. 1980 Oct;17(5):385-7.
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The assay of uridine diphosphoglucose dehydrogenase activity: discrimination from xanthine dehydrogenase activity.尿苷二磷酸葡萄糖脱氢酶活性的测定:与黄嘌呤脱氢酶活性的区分
Cell Biochem Funct. 1991 Apr;9(2):103-10. doi: 10.1002/cbf.290090207.

引用本文的文献

1
Reconstruction of an in vitro niche for the transition from intervertebral disc development to nucleus pulposus regeneration.构建椎间盘发育向髓核组织再生转变的体外龛位
Stem Cells Dev. 2013 Apr 15;22(8):1162-76. doi: 10.1089/scd.2012.0597. Epub 2013 Feb 15.

本文引用的文献

1
Glycosaminoglycans of cat intervertebral disc.猫椎间盘的糖胺聚糖
Biochem J. 1971 May;122(5):647-52. doi: 10.1042/bj1220647.