常规眼底镜检查后近乎致命的抗胆碱能中毒

Near fatal anticholinergic intoxication after routine fundoscopy.

作者信息

Brunner G A, Fleck S, Pieber T R, Lueger A, Kaufmann P, Smolle K H, Brussee H, Krejs G J

机构信息

Department of Internal Medicine, Karl Franzens University Graz, Austria.

出版信息

Intensive Care Med. 1998 Jul;24(7):730-1. doi: 10.1007/s001340050652.

DOI:10.1007/s001340050652

PMID:9722045

Abstract

We describe a case of severe anticholinergic intoxication following the topical instillation of tropicamide-containing eyedrops. Tropicamide is a short-acting atropine-like derivative and has been regarded as an effective and safe mydriatic. Half an hour after routine fundoscopy, a 62-year-old man experienced two generalized seizures with respiratory arrest and required intubation and mechanical ventilation. The patient was treated with physostigmine and made a full recovery.

摘要

我们描述了一例因局部滴注含托吡卡胺的眼药水后发生严重抗胆碱能中毒的病例。托吡卡胺是一种短效的阿托品样衍生物，一直被认为是一种有效且安全的散瞳剂。在常规眼底检查半小时后，一名62岁男性出现两次全身性癫痫发作并伴有呼吸骤停，需要进行插管和机械通气。该患者接受了毒扁豆碱治疗并完全康复。