Saraçoğlu F, Göl K, Sahin I, Türkkani B, Atalay C, Oztopçu C
Department of Obstetrics and Gynecology, Numune Hospital, Ankara, Turkey.
Int J Gynaecol Obstet. 1998 Jul;62(1):59-61. doi: 10.1016/s0020-7292(98)00029-0.
To evaluate the clinical efficacy and tolerance of oral or vaginal ornidazole, secnidazole and metronidazole or their combinations for treatment of bacterial vaginosis.
In an open, randomized, prospective study, 152 patients with bacterial vaginosis according to Amsel's criteria were included into the study. The patients were divided into eight groups: (1) oral ornidazole 2 x 500 mg/day for 5 days; (2) vaginal ornidazole 500 mg/day for 5 days; (3) oral and vaginal ornidazole for 5 days; (4) oral secnidazole 2 g in a single dose; (5) oral secnidazole 2 g in a single dose and vaginal ornidazole 500 mg/day for 5 days; (6) oral secnidazole 2 g in a single dose and vaginal metronidazole 2 x 500 mg/day for 7 days; (7) oral ornidazole 2 x 500 mg/day for 5 days and vaginal metronidazole 2 x 500 mg/day for 7 days; and (8) vaginal metronidazole 2 x 500 mg/day for 7 days. None of the partners received any treatment.
We found a 100% cure rate in both oral and vaginal ornidazole and oral secnidazole-vaginal metronidazole groups.
Vaginal treatments including ornidazole and metronidazole are not as effective as both oral and vaginal drug combinations.
评估口服或阴道用奥硝唑、塞克硝唑和甲硝唑及其联合用药治疗细菌性阴道病的临床疗效和耐受性。
在一项开放、随机、前瞻性研究中，根据阿姆塞尔标准纳入152例细菌性阴道病患者。患者被分为八组：（1）口服奥硝唑，每日2次，每次500mg，共5天；（2）阴道用奥硝唑，每日500mg，共5天；（3）口服和阴道用奥硝唑，共5天；（4）口服塞克硝唑，单次剂量2g；（5）口服塞克硝唑单次剂量2g，同时阴道用奥硝唑，每日500mg，共5天；（6）口服塞克硝唑单次剂量2g，同时阴道用甲硝唑，每日2次，每次500mg，共7天；（7）口服奥硝唑，每日2次，每次500mg，共5天，同时阴道用甲硝唑，每日2次，每次500mg，共7天；（8）阴道用甲硝唑，每日2次，每次500mg，共7天。所有性伴侣均未接受任何治疗。
我们发现口服和阴道用奥硝唑组以及口服塞克硝唑 - 阴道用甲硝唑组的治愈率均为100%。
包括奥硝唑和甲硝唑在内的阴道用药治疗不如口服与阴道联合用药有效。
