Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Indian J Pharmacol. 2012 Mar;44(2):243-5. doi: 10.4103/0253-7613.93859.
To compare the cure rates of oral single dose of metronidazole (2 g), tinidazole (2 g), secnidazole (2 g), and ornidazole (1.5 g) in cases of bacterial vaginosis.
This was a prospective, comparative, randomized clinical trial on 344 Indian women (86 women in each group) who attended a gynecology outpatient department with complaint of abnormal vaginal discharge or who had abnormal vaginal discharge on Gynecological examination but they did not complaint of it. For diagnosis and cure rate of bacterial vaginosis, Amsel's criteria were used. Statistical analysis was done by Chi-square test of proportions. The cure rate was compared considering metronidazole cure rate as gold standard.
At 1 week, the cure rate of tinidazole and ornidazole was 100% and at 4 weeks, it was 97.7% for both drugs (P<0.001). Secnidazole had cure rate of 80.2% at 4 weeks (P=NS). Metronidazole showed a cure rate of 77.9% at 4 weeks, which is the lowest of all four drugs.
Tinidazole and ornidazole have better cure rate as compared to metronidazole in cases of bacterial vaginosis.
比较细菌性阴道病患者单次口服甲硝唑（2g）、替硝唑（2g）、司帕沙星（2g）和奥硝唑（1.5g）的治愈率。
这是一项前瞻性、比较性、随机临床试验，纳入了 344 名印度女性（每组 86 名），这些女性因异常阴道分泌物就诊妇科门诊，或在妇科检查中发现异常阴道分泌物但无相关主诉。细菌性阴道病的诊断和治愈率采用 Amsel 标准。采用比例卡方检验进行统计学分析。以甲硝唑的治愈率为金标准，比较治愈率。
治疗 1 周时，替硝唑和奥硝唑的治愈率为 100%，4 周时的治愈率均为 97.7%（P<0.001）。司帕沙星在 4 周时的治愈率为 80.2%（P=NS）。甲硝唑在 4 周时的治愈率为 77.9%，是四种药物中最低的。
在细菌性阴道病患者中，替硝唑和奥硝唑的治愈率优于甲硝唑。
