Diegoli M S, da Fonseca A M, Diegoli C A, Pinotti J A
Department of Gynecology and Obstetrics, University of São Paulo, Brazil.
Int J Gynaecol Obstet. 1998 Jul;62(1):63-7. doi: 10.1016/s0020-7292(98)00035-6.
To determine the efficacy of fluoxetine (10 mg), alprazolam, propanolol and pyridoxine in the treatment of severe premenstrual syndrome (PMS).
One-hundred and twenty women were divided into four groups of 30 patients. Patients were submitted to a randomized, double-blind, placebo-controlled treatment and were given 3 months of placebo and 3 months of active drug. The active drug was pyridoxine (300 mg/day) in group 1; alprazolam (0.75 mg/day) in group 2; fluoxetine (10 mg/day) in group 3; and propanolol (20 mg/day and 40 mg during the menstrual period) in group 4.
Fluoxetine in 10-mg doses obtained a mean reduction of 65.4% in symptoms, followed by propanolol (58.7%), alprazolam (55.6%), pyridoxine (45.3%) and placebo (39.4-46.1%).
Fluoxetine in 10-mg doses presented the best results for treating premenstrual syndrome.
确定氟西汀（10毫克）、阿普唑仑、普萘洛尔和吡哆醇治疗重度经前综合征（PMS）的疗效。
120名女性被分为四组，每组30名患者。患者接受随机、双盲、安慰剂对照治疗，服用3个月安慰剂和3个月活性药物。第1组活性药物为吡哆醇（300毫克/天）；第2组为阿普唑仑（0.75毫克/天）；第3组为氟西汀（10毫克/天）；第4组为普萘洛尔（20毫克/天，经期40毫克）。
10毫克剂量的氟西汀使症状平均减轻65.4%，其次是普萘洛尔（58.7%）、阿普唑仑（55.6%）、吡哆醇（45.3%）和安慰剂（39.4 - 46.1%）。
10毫克剂量的氟西汀治疗经前综合征效果最佳。
