Ozeren S, Corakçi A, Yücesoy I, Mercan R, Erhan G
University of Kocaeli, School of Medicine, Department of Obstetrics and Gynecology, Turkey.
Eur J Obstet Gynecol Reprod Biol. 1997 Jun;73(2):167-70. doi: 10.1016/s0301-2115(97)02741-3.
Premenstrual syndrome (PMS) is defined as the disabling and cyclic occurrence of emotional and behavioral symptom complex during the latter half of the menstrual cycle. Although its etiology is unknown, it has been speculated that premenstrual syndrome is linked to a deficiency of central serotoninergic activity.
The study consisted of a double-blind, placebo controlled trial of fluoxetine at a dose of 20 mg/day or placebo for three menstrual cycles. The 440 women who appeared to meet the eligibility criteria were instructed to record the 'Calendar of Premenstrual Experiences' (CPE) scale for two complete menstrual cycles. Of 410 women who successfully completed two cycles of recording their symptoms daily only 35 met the criteria for PMS. These criteria included psychiatric interviews which were made before treatment. Thirty-five PMS patients were randomized into placebo or fluoxetine treatment groups.
Our study suggests that fluoxetine at a dose of 20 mg per day was significantly superior to placebo in alleviating the symptoms of PMS. The most common side effects were gastrointestinal irritability (15%), insomnia (11%) and sexual dysfunction (8.5%).
Fluoxetine is an effective and well-tolerated drug and appears to have considerable promise in treating a range of symptoms in women with PMS.
经前综合征（PMS）被定义为在月经周期后半段出现的导致功能障碍的周期性情绪和行为症状复合体。尽管其病因不明，但据推测经前综合征与中枢5-羟色胺能活性不足有关。
该研究包括一项双盲、安慰剂对照试验，使用20毫克/天的氟西汀或安慰剂，为期三个月经周期。440名似乎符合入选标准的女性被要求记录两个完整月经周期的“经前经历日历”（CPE）量表。在410名成功完成两个周期每日症状记录的女性中，只有35名符合经前综合征标准。这些标准包括治疗前进行的精神科访谈。35名经前综合征患者被随机分为安慰剂组或氟西汀治疗组。
我们的研究表明，每天20毫克剂量的氟西汀在缓解经前综合征症状方面明显优于安慰剂。最常见的副作用是胃肠道不适（15%）、失眠（11%）和性功能障碍（8.5%）。
氟西汀是一种有效且耐受性良好的药物，在治疗经前综合征女性的一系列症状方面似乎有很大前景。
