加巴喷丁对小鼠脑γ-氨基丁酸（GABA）-α-酮戊二酸转氨酶的不可逆抑制作用。 - Suppr

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超能文献

The irreversible inhibition of mouse brain gamma-aminobutyric acid (GABA)-alpha-ketoglutaric acid transaminase by gabaculine.

作者信息

Rando R R, Bangerter F W

出版信息

J Am Chem Soc. 1976 Oct 13;98(21):6762-4. doi: 10.1021/ja00437a090.

DOI:10.1021/ja00437a090

PMID:972233

Abstract

摘要

相似文献

The irreversible inhibition of mouse brain gamma-aminobutyric acid (GABA)-alpha-ketoglutaric acid transaminase by gabaculine.加巴喷丁对小鼠脑γ-氨基丁酸（GABA）-α-酮戊二酸转氨酶的不可逆抑制作用。

J Am Chem Soc. 1976 Oct 13;98(21):6762-4. doi: 10.1021/ja00437a090.

The in vivo inhibition of GABA-transaminase by gabaculine.加巴喷丁对体内γ-氨基丁酸转氨酶的抑制作用。

Biochem Biophys Res Commun. 1977 Jun 20;76(4):1276-81. doi: 10.1016/0006-291x(77)90993-7.

Effects of gabaculine, a new potent inhibitor of gamma-amonobutyrate transaminase, on the brain gamma-amonobutyrate content and convulsions in mice.新型强效γ-氨基丁酸转氨酶抑制剂加巴卡林对小鼠脑γ-氨基丁酸含量及惊厥的影响

Life Sci. 1977 Apr 1;20(7):1291-5. doi: 10.1016/0024-3205(77)90505-7.

Inhibition of aminotransferase enzyme systems by gabaculine.加巴喷丁对转氨酶酶系统的抑制作用。

Neurosci Lett. 1979 Oct;14(2-3):327-31. doi: 10.1016/0304-3940(79)96169-x.

The inactivation of gamma-aminobutyric acid transaminase in dissociated neuronal cultures from spinal cord.脊髓解离神经元培养物中γ-氨基丁酸转氨酶的失活

J Neurochem. 1981 Mar;36(3):985-90. doi: 10.1111/j.1471-4159.1981.tb01690.x.

Molecular basis for the irreversible inhibition of 4-aminobutyric acid:2-oxoglutarate and L-ornithine:2-oxoacid aminotransferases by 3-amino-1,5-cyclohexadienyl carboxylic acid (isogabaculline).3-氨基-1,5-环己二烯基羧酸（异加巴咕啉）对4-氨基丁酸：2-氧代戊二酸转氨酶和L-鸟氨酸：2-氧代酸转氨酶不可逆抑制的分子基础

Mol Pharmacol. 1979 Sep;16(2):539-45.

Gabuculine and isogabaculine: in vivo biochemistry and pharmacology in mice.加布可林和异加布可林：小鼠体内生物化学与药理学研究

Life Sci. 1979 Mar 26;24(13):1173-82. doi: 10.1016/0024-3205(79)90054-7.

The use of inhibitors of GABA-transaminase for the determination of GABA turnover in mouse brain regions: an evaluation of aminooxyacetic acid and gabaculine.使用γ-氨基丁酸转氨酶抑制剂测定小鼠脑区γ-氨基丁酸的周转率：对氨氧基乙酸和加巴喷丁的评估

J Neurochem. 1982 Jan;38(1):57-66. doi: 10.1111/j.1471-4159.1982.tb10853.x.

Irreversible inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by gabaculine.加巴喷丁对D-3-氨基异丁酸-丙酮酸转氨酶的不可逆抑制作用。

FEBS Lett. 1990 Dec 10;276(1-2):115-8. doi: 10.1016/0014-5793(90)80521-j.

3-Mercaptopropionic acid: convulsant properties, effects on enzymes of the gamma-aminobutyrate system in mouse brain and antagonism by certain anticonvulsant drugs, aminooxyacetic acid and gabaculine.3-巯基丙酸：惊厥特性、对小鼠脑内γ-氨基丁酸系统酶的影响以及某些抗惊厥药物（氨氧基乙酸和加巴脲）的拮抗作用。

Biochem Pharmacol. 1979 Apr 15;28(8):1397-407. doi: 10.1016/0006-2952(79)90443-x.

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Biochem Biophys Res Commun. 2020 Feb 12;522(3):633-638. doi: 10.1016/j.bbrc.2019.11.130. Epub 2019 Nov 28.

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Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds.非蛋白氨基酸砌块用于构建非核糖体肽和杂合聚酮骨架。

Angew Chem Int Ed Engl. 2013 Jul 8;52(28):7098-124. doi: 10.1002/anie.201208344. Epub 2013 May 31.

Biosynthesis of Tetrapyrrole Pigment Precursors : Pyridoxal Requirement of the Aminotransferase Step in the Formation of delta-Aminolevulinate from Glutamate in Extracts of Chlorella vulgaris.四吡咯色素前体的生物合成：钝顶螺旋藻提取物中谷氨酸生成 δ-氨基乙酰丙酸的转氨酶步骤需要吡哆醛。

Plant Physiol. 1989 Mar;89(3):852-9. doi: 10.1104/pp.89.3.852.

4-amino-5-hexynoic Acid-a potent inhibitor of tetrapyrrole biosynthesis in plants.4-氨基-5-己炔酸——一种植物中四吡咯生物合成的有效抑制剂。

Plant Physiol. 1988 Nov;88(3):747-51. doi: 10.1104/pp.88.3.747.

Phytochrome Chromophore Biosynthesis : Both 5-Aminolevulinic Acid and Biliverdin Overcome Inhibition by Gabaculine in Etiolated Avena sativa L. Seedlings.光敏色素生色团生物合成：5-氨基乙酰丙酸和胆绿素均可克服 Gabaculine 对黄化燕麦幼苗的抑制作用。

Plant Physiol. 1987 Jun;84(2):304-10. doi: 10.1104/pp.84.2.304.

The effect of sodium-n-dipropyl acetate on gamma-aminobutyric acid-dependent inhibition in the rat cortex and substantia nigra in relation to its anticonvulsant activity.醋酸正丙酯钠对大鼠皮层和黑质中γ-氨基丁酸依赖性抑制作用及其抗惊厥活性的影响。

Br J Pharmacol. 1980;71(2):545-51. doi: 10.1111/j.1476-5381.1980.tb10971.x.

Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.大脑中γ-氨基丁酸的细胞区室及其与抗惊厥活性的关系。

Mol Cell Biochem. 1981 Sep 25;39:305-29. doi: 10.1007/BF00232582.

5-Fluoromethylornithine, an irreversible and specific inhibitor of L-ornithine:2-oxo-acid aminotransferase.5-氟甲基鸟氨酸，一种L-鸟氨酸：2-氧代酸氨基转移酶的不可逆特异性抑制剂。

Biochem J. 1988 Jul 15;253(2):481-8. doi: 10.1042/bj2530481.

Interrelationships between ornithine, glutamate, and GABA. II. Consequences of inhibition of GABA-T and ornithine aminotransferase in brain.鸟氨酸、谷氨酸和γ-氨基丁酸之间的相互关系。II. 脑内γ-氨基丁酸转氨酶和鸟氨酸转氨酶抑制的后果

Neurochem Res. 1988 Jan;13(1):69-75. doi: 10.1007/BF00971857.

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