p59OASL，一种2'-5'寡腺苷酸合成酶样蛋白：一个与2'-5'寡腺苷酸合成酶家族相关的新型人类基因。
p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family.
作者信息
Hartmann R, Olsen H S, Widder S, Jorgensen R, Justesen J
机构信息
Department of Molecular and Structural Biology, University of Aarhus, C. F. Mollers allé Building 130, DK-8000 Aarhus C, Denmark and Human Genome Sciences Inc., 9410 Key West Avenue, Rockville, MD 20850, USA.
出版信息
Nucleic Acids Res. 1998 Sep 15;26(18):4121-8. doi: 10.1093/nar/26.18.4121.
Abstract
The 2'-5' oligoadenylate synthetases form a well conserved family of interferon induced proteins, presumably present throughout the mammalian class. Using the Expressed Sequence Tag databases, we have identified a novel member of this family. This protein, which we named p59 2'-5' oligoadenylate synthetase-like protein (p59OASL), shares a highly conserved N-terminal domain with the known forms of 2'-5' oligoadenylate synthetases, but differs completely in its C-terminal part. The C-terminus of p59OASL is formed of two domains of ubiquitin-like sequences. Here we present the characterisation of a full-length cDNA clone, the genomic sequence and the expression pattern of this gene. We have addressed the evolution of the 2'-5' oligoadenylate synthetase gene family, in the light of both this new member and new 2'-5' oligoadenylate synthetase sequence data from other species, which have recently appeared in the databases.
摘要
2'-5'寡腺苷酸合成酶构成了一个干扰素诱导蛋白的保守家族，可能存在于整个哺乳纲动物中。利用表达序列标签数据库，我们鉴定出了该家族的一个新成员。这种蛋白，我们将其命名为p59 2'-5'寡腺苷酸合成酶样蛋白（p59OASL），与已知形式的2'-5'寡腺苷酸合成酶共享一个高度保守的N端结构域，但其C端部分则完全不同。p59OASL的C端由两个泛素样序列结构域组成。在此，我们展示了该基因全长cDNA克隆的特征、基因组序列及其表达模式。鉴于这个新成员以及数据库中最近出现的来自其他物种的新2'-5'寡腺苷酸合成酶序列数据，我们探讨了2'-5'寡腺苷酸合成酶基因家族的进化。
相似文献
1
p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family.p59OASL，一种2'-5'寡腺苷酸合成酶样蛋白：一个与2'-5'寡腺苷酸合成酶家族相关的新型人类基因。
Nucleic Acids Res. 1998 Sep 15;26(18):4121-8. doi: 10.1093/nar/26.18.4121.
2
3
Gene structure and function of the 2'-5'-oligoadenylate synthetase family.2'-5'-寡腺苷酸合成酶家族的基因结构与功能
Cell Mol Life Sci. 2000 Oct;57(11):1593-612. doi: 10.1007/pl00000644.
4
Differential action of natural selection on the N and C-terminal domains of 2'-5' oligoadenylate synthetases and the potential nuclease function of the C-terminal domain.自然选择对2'-5'寡腺苷酸合成酶的N端和C端结构域的差异作用以及C端结构域的潜在核酸酶功能。
J Mol Biol. 2003 Mar 7;326(5):1449-61. doi: 10.1016/s0022-2836(03)00055-x.
5
Molecular cloning, characterization, and expression of duck 2'-5'-oligoadenylate synthetase-like gene.鸭2'-5'-寡腺苷酸合成酶样基因的分子克隆、特征分析及表达
Gene. 2017 Sep 20;629:43-51. doi: 10.1016/j.gene.2017.07.067. Epub 2017 Jul 25.
6
Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family.小鼠2',5'-寡腺苷酸合成酶基因家族的基因组结构。
J Interferon Cytokine Res. 2002 Sep;22(9):981-93. doi: 10.1089/10799900260286696.
7
The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain.p59寡腺苷酸合成酶样蛋白具有抗病毒活性，这种活性需要C末端类泛素结构域。
J Gen Virol. 2008 Nov;89(Pt 11):2767-2772. doi: 10.1099/vir.0.2008/003558-0.
8
Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family.2'-5'-寡腺苷酸合成酶类泛素家族的特征分析
Nucleic Acids Res. 2003 Jun 15;31(12):3166-73. doi: 10.1093/nar/gkg427.
9
The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla.哺乳动物2'-5'寡腺苷酸合成酶基因家族：啮齿目和偶蹄目旁系同源Oas1基因协同进化的证据。
J Mol Evol. 2006 Oct;63(4):562-76. doi: 10.1007/s00239-006-0073-3. Epub 2006 Oct 5.
10
Origin of the interferon-inducible (2'-5')oligoadenylate synthetases: cloning of the (2'-5')oligoadenylate synthetase from the marine sponge Geodia cydonium.干扰素诱导型（2'-5'）寡腺苷酸合成酶的起源：来自海洋海绵Geodia cydonium的（2'-5'）寡腺苷酸合成酶的克隆
FEBS Lett. 1999 Nov 26;462(1-2):12-8. doi: 10.1016/s0014-5793(99)01478-7.
引用本文的文献
1
OASL suppresses infectious bursal disease virus replication by targeting VP2 for degrading through the autophagy pathway.OASL 通过靶向 VP2 并通过自噬途径使其降解来抑制传染性腔上囊病病毒的复制。
J Virol. 2024 May 14;98(5):e0018124. doi: 10.1128/jvi.00181-24. Epub 2024 Apr 19.
2
Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production.寡聚腺苷酸合成酶 1 通过驱动翻译关闭和保护干扰素产生来发挥双重抗病毒机制。
Immunity. 2024 Mar 12;57(3):446-461.e7. doi: 10.1016/j.immuni.2024.02.002. Epub 2024 Feb 28.
3
The Many Faces of Oligoadenylate Synthetases.寡聚腺苷酸合成酶的多面性。
J Interferon Cytokine Res. 2023 Nov;43(11):487-494. doi: 10.1089/jir.2023.0098. Epub 2023 Sep 25.
4
Pan-cancer analysis identified OAS1 as a potential prognostic biomarker for multiple tumor types.泛癌分析确定OAS1为多种肿瘤类型的潜在预后生物标志物。
Front Oncol. 2023 Sep 6;13:1207081. doi: 10.3389/fonc.2023.1207081. eCollection 2023.
5
Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family.封闭蛋白通过调节干扰素刺激的 OAS 基因家族调节 HIV-1 感染。
Mol Neurobiol. 2023 Sep;60(9):4966-4982. doi: 10.1007/s12035-023-03381-0. Epub 2023 May 20.
6
Occludin regulates HIV-1 infection by modulation of the interferon stimulated OAS gene family.闭合蛋白通过调节干扰素刺激的寡腺苷酸合成酶（OAS）基因家族来调控HIV-1感染。
Res Sq. 2023 Jan 30:rs.3.rs-2501091. doi: 10.21203/rs.3.rs-2501091/v1.
7
Dance with the Devil: Stress Granules and Signaling in Antiviral Responses.与魔鬼共舞：应激颗粒与抗病毒反应中的信号传导
Viruses. 2020 Sep 4;12(9):984. doi: 10.3390/v12090984.
8
One Step Ahead: Herpesviruses Light the Way to Understanding Interferon-Stimulated Genes (ISGs).先行一步：疱疹病毒为理解干扰素刺激基因（ISGs）指明方向。
Front Microbiol. 2020 Feb 7;11:124. doi: 10.3389/fmicb.2020.00124. eCollection 2020.
9
Characteristics of Human OAS1 Isoform Proteins.人 OAS1 同工型蛋白的特性。
Viruses. 2020 Jan 29;12(2):152. doi: 10.3390/v12020152.
10
Double-Stranded RNA Sensors and Modulators in Innate Immunity.双链 RNA 传感器和先天免疫调节剂。
Annu Rev Immunol. 2019 Apr 26;37:349-375. doi: 10.1146/annurev-immunol-042718-041356. Epub 2019 Jan 23.
本文引用的文献
1
Virus-induced cell death in plants expressing the mammalian 2',5' oligoadenylate system.在表达哺乳动物2',5'-寡腺苷酸系统的植物中病毒诱导的细胞死亡
Nat Biotechnol. 1996 Nov;14(11):1566-9. doi: 10.1038/nbt1196-1566.
2
Diadenosine oligophosphates (Ap(n)A), a novel class of signalling molecules?二腺苷寡磷酸（Ap(n)A），一类新型信号分子？
FEBS Lett. 1998 May 8;427(2):157-63. doi: 10.1016/s0014-5793(98)00420-7.
3
Activation of 2'-5' oligoadenylate synthetase by single-stranded and double-stranded RNA aptamers.单链和双链RNA适体对2'-5'寡腺苷酸合成酶的激活作用。
J Biol Chem. 1998 Feb 6;273(6):3236-46. doi: 10.1074/jbc.273.6.3236.
4
Expressed sequence tags--ESTablishing bridges between genomes.表达序列标签——在基因组之间架起桥梁。
Trends Genet. 1998 Jan;14(1):4-7. doi: 10.1016/S0168-9525(97)01355-3.
5
Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein.2'-5'-寡腺苷酸合成酶的酶活性会受到影响该蛋白质寡聚化的特定突变的损害。
J Biol Chem. 1997 Dec 26;272(52):33220-6. doi: 10.1074/jbc.272.52.33220.
6
Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL.转录调控数据库：TRANSFAC、TRRD和COMPEL。
Nucleic Acids Res. 1998 Jan 1;26(1):362-7. doi: 10.1093/nar/26.1.362.
7
Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L.在缺乏2',5'-寡腺苷酸依赖性核糖核酸酶L的小鼠中，干扰素作用和细胞凋亡存在缺陷。
EMBO J. 1997 Nov 3;16(21):6355-63. doi: 10.1093/emboj/16.21.6355.
8
Effects of mutating specific residues present near the amino terminus of 2'-5'-oligoadenylate synthetase.
J Biol Chem. 1997 Jun 13;272(24):15452-8. doi: 10.1074/jbc.272.24.15452.
9
Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6.起始密码子AUG及其他起始密码子在+4位为G时识别增强，但一般不受+5和+6位核苷酸的影响。
EMBO J. 1997 May 1;16(9):2482-92. doi: 10.1093/emboj/16.9.2482.
10
On beyond classic RACE (rapid amplification of cDNA ends).超越经典的RACE（cDNA末端快速扩增）。
PCR Methods Appl. 1994 Aug;4(1):S40-58. doi: 10.1101/gr.4.1.s40.
Zotero 插件