Dobbs S M, Mawer G E
J Infect Dis. 1976 Aug;134 Suppl:S114-7. doi: 10.1093/infdis/134.supplement_1.s114.
The aminoglycoside antibiotics gentamicin and tobramycin were given to six healthy volunteers by intravenous injection. A dose of 80 mg was injected within 1 min. The curves relating serum concentration to time did not differ significantly for the two drugs. The maximal serum concentrations of drug exceeded 10 mug/ml on seven of 12 occasions. Despite these high concentrations, loss of hearing was not significant at any frequency (1,000-8,000 Hz) up to one month after injection. It is suggested that the aminoglycoside antibiotics penetrate into the inner ear lymph very slowly and that the concentration at that site is relatively unaffected by transient high concentrations of antibiotic in the blood plasma.
对6名健康志愿者静脉注射氨基糖苷类抗生素庆大霉素和妥布霉素。在1分钟内注射80毫克剂量。两种药物的血清浓度与时间的曲线无显著差异。在12次检测中有7次药物的血清最大浓度超过10微克/毫升。尽管有这些高浓度，但在注射后长达1个月的时间里，任何频率（1000 - 8000赫兹）的听力损失都不显著。有人提出，氨基糖苷类抗生素非常缓慢地渗入内耳淋巴液，并且该部位的浓度相对不受血浆中抗生素瞬时高浓度的影响。
