Cohen J D, Miale T D
J Infect Dis. 1976 Aug;134 Suppl:S175-7.
The safety and efficacy of tobramycin and cephalothin in treatment of suspected sepsis were studied in neutropenic children with various malignancies. Twenty episodes of suspected sepsis in 19 febrile children with cancer were treated with parenteral tobramycin and cephalothin; the duration of therapy ranged from one to 80 days. In 14 of the 20 episodes of suspected sepsis, a favorable clinical response was achieved within five days after initiation of antibiotic therapy. These episodes included a urinary tract infection with Proteus mirabilis and sepsis due to Escherichia coli. In four of the additional six episodes, clinical deterioration was though to be caused by the underlying malignancies. Two episodes included a case of E. coli spesis that ended fatally and a nosocomial infection with Eikenella corrodens. Results of this study suggest that combination therapy with tobramycin and cephalothin is safe and efficacious in treatment of suspected sepsis in febrile children with malignancies and neutropenia.
在患有各种恶性肿瘤的中性粒细胞减少儿童中，研究了妥布霉素和头孢噻吩治疗疑似败血症的安全性和有效性。对19名发热癌症患儿的20例疑似败血症发作采用静脉注射妥布霉素和头孢噻吩进行治疗；治疗持续时间为1至80天。在20例疑似败血症发作中，有14例在开始抗生素治疗后5天内取得了良好的临床反应。这些发作包括奇异变形杆菌引起的尿路感染和大肠杆菌引起的败血症。在另外6例发作中，有4例临床恶化被认为是由潜在的恶性肿瘤引起的。其中2例发作包括1例致命的大肠杆菌败血症病例和1例腐蚀艾肯菌医院感染病例。本研究结果表明，妥布霉素和头孢噻吩联合治疗对患有恶性肿瘤和中性粒细胞减少的发热儿童疑似败血症是安全有效的。
