Sommer G, Corrigan G, Fredrickson J, Sawyer-Glover A, Liao J R, Myers B, Pelc N
Department of Radiology, Stanford University Medical Center CA 94305-5105, USA.
Radiology. 1998 Sep;208(3):729-34. doi: 10.1148/radiology.208.3.9722853.
To assess the ability of three cine phase-contrast magnetic resonance (MR) imaging techniques to measure normal human renal blood flow (RBF) in vivo.
Eighteen healthy volunteers were studied with three cine phase-contrast MR imaging techniques: breath-hold, segmented k-space, two-dimensional, Fourier transform technique (ie, time-resolved imaging with automatic data segmentation, or TRIADS); a breath-hold rapid spiral acquisition; and a non-breath-hold rapid spiral acquisition that allowed resolution of both cardiac and respiratory cycles. In each case, total arterial RBF and blood flow per unit of renal volume were calculated. For each subject, RBF was measured with a standard technique of p-aminohippuric acid (PAH)-clearance hematocrit on the same day as the MR imaging examination was performed.
The range of agreement (2 standard deviations, or 95% confidence interval) between RBF measurements obtained with the PAH-clearance hematocrit technique and the various cine phase-contrast techniques varied from +/- 17.6% to +/- 26.5%. The best agreement was obtained with non-breath-hold rapid spiral data, by using data from the end-expiratory phase of respiration.
Findings with cine phase-contrast MR imaging employing rapid spiral acquisition are in good agreement with measurements made with PAH-clearance hematocrit and give the promise of clinical measurements of RBF.
评估三种电影相位对比磁共振（MR）成像技术在体内测量正常人体肾血流量（RBF）的能力。
对18名健康志愿者采用三种电影相位对比MR成像技术进行研究：屏气分段k空间二维傅里叶变换技术（即自动数据分割时间分辨成像，或TRIADS）；屏气快速螺旋采集；以及一种可分辨心动周期和呼吸周期的非屏气快速螺旋采集。在每种情况下，计算总动脉RBF和每单位肾体积的血流量。对于每个受试者，在进行MR成像检查的同一天，采用对氨基马尿酸（PAH）清除率血细胞比容的标准技术测量RBF。
PAH清除率血细胞比容技术与各种电影相位对比技术所测得的RBF之间的一致性范围（2个标准差，即95%置信区间）在±17.6%至±26.5%之间。通过使用呼气末期的非屏气快速螺旋数据获得了最佳一致性。
采用快速螺旋采集的电影相位对比MR成像结果与PAH清除率血细胞比容测量结果高度一致，并有望用于RBF的临床测量。
