Hertzberg B S, Kliewer M A, Bowie J D, McNally P J
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Radiology. 1998 Sep;208(3):795-8. doi: 10.1148/radiology.208.3.9722862.
To test the strength of the association of cholecystomegaly with aneuploidy and biliary abnormality and to assess the prognostic importance of the detection of an enlarged fetal gallbladder at antenatal ultrasonography (US).
Gallbladder size was prospectively evaluated during 842 consecutive second-and third-trimester US examinations in 775 fetuses. The area of the gallbladder was calculated on the image that depicted the maximal gallbladder size, and the actual gallbladder areas was compared with the gallbladder area expected on the basis of the gestational age. Fetuses with an enlarged gallbladder were followed up.
Forty-three fetuses had an enlarged gallbladder (area more than 2 SDs above the mean for gestational age). Outcome was normal in 38 of the 39 fetuses who could be followed up. With the exception of a single baby with an isolated ventricular septal defect, which closed spontaneously, none of the babies with an enlarged fetal gallbladder had structural anatomic defects or evidence of aneuploidy or a biliary tract abnormality.
Identification of an enlarged gallbladder at antenatal US does not appear to be associated with a substantially increased risk of chromosomal aneuploidy or biliary tract malformation.
检验胆囊增大与非整倍体及胆道异常之间关联的强度，并评估产前超声检查（US）时检测到胎儿胆囊增大的预后重要性。
前瞻性评估了775例胎儿连续842次孕中期和孕晚期超声检查期间的胆囊大小。在描绘胆囊最大尺寸的图像上计算胆囊面积，并将实际胆囊面积与基于孕周预期的胆囊面积进行比较。对胆囊增大的胎儿进行了随访。
43例胎儿胆囊增大（面积超过孕周均值2个标准差以上）。在39例可随访的胎儿中，38例结局正常。除1例孤立性室间隔缺损婴儿自行闭合外，胎儿胆囊增大的婴儿均无结构解剖缺陷、非整倍体证据或胆道异常。
产前超声检查发现胆囊增大似乎与染色体非整倍体或胆道畸形风险大幅增加无关。
