Hertzberg B S, Kliewer M A, Maynor C, McNally P J, Bowie J D, Kay H H, Hage M L, Livingston E
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Radiology. 1996 Jun;199(3):679-82. doi: 10.1148/radiology.199.3.8637986.
To assess the frequency of fetal gallbladder visualization through gestation and to determine the prognostic importance of nonvisualization.
Demonstration of the gallbladder was prospectively attempted in 578 consecutive second- and third-trimester obstetric ultrasound examinations. Data regarding gallbladder visualization were stratified into subgroups on the basis of estimated gestational age. Postnatal follow-up was performed in 80 fetuses with nonvisualization of the gallbladder.
The gallbladder was seen on 477 of 578 (82.5%) fetal sonograms. The likelihood of gallbladder visualization increased with advancing gestational age, reaching a plateau of approximately 95% between 24 and 32 weeks. After 32 weeks, the frequency of visualization declined. Seventy-five of the 80 fetuses with nonvisualized gallbladders who underwent follow-up had normal outcomes. Except for one fetus with trisomy 21, all fetuses with abnormalities had relatively minor, non-life threatening problems that did not involve the gallbladder or biliary tract.
Most fetuses with nonvisualization of the gallbladder have normal outcomes. The rate of nonvisualization of the fetal gallbladder is sufficiently high to undermine the utility of gallbladder visualization as a screen for fetal abnormality.
评估整个孕期胎儿胆囊可视化的频率，并确定胆囊未可视化的预后重要性。
在连续578例孕中期和孕晚期产科超声检查中前瞻性地尝试显示胆囊。根据估计的孕周将胆囊可视化的数据分层为亚组。对80例胆囊未可视化的胎儿进行了产后随访。
在578例胎儿超声检查中，有477例（82.5%）可见胆囊。胆囊可视化的可能性随着孕周的增加而增加，在24至32周之间达到约95%的平台期。32周后，可视化频率下降。80例胆囊未可视化且接受随访的胎儿中，75例结局正常。除1例21三体胎儿外，所有异常胎儿均有相对轻微、不危及生命的问题，且不涉及胆囊或胆道。
大多数胆囊未可视化的胎儿结局正常。胎儿胆囊未可视化的发生率足够高，足以削弱胆囊可视化作为胎儿异常筛查手段的效用。
