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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Ben-Shahar O, Ettenberg A

Department of Psychology, University of California, Santa Barbara, USA.

Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):763-73. doi: 10.1016/s0278-5846(98)00038-4.

Adult male rats were implanted with chronic medial prefrontal cortex cannulae. 2. On each of 5 consecutive days, rats received bilateral 0.5 ml intra-prefrontal cortex injections of either 5 mg d-amphetamine or saline, followed by a subcutaneous injection of either 1 mg/kg d-amphetamine or saline. 3. Immediately after the drug treatments each rat was placed into a photocell equipped locomotor activity chamber for 60 min. 4. Administration of d-amphetamine into the prefrontal cortex did not block the acute locomotor response to subcutaneous d-amphetamine nor did it in itself produce an increase in locomotor activity. However, prefrontal cortex amphetamine treatments did attenuate the sensitized locomotor effects of subcutaneous amphetamine that developed over trials/days. 5. Dopamine in the prefrontal cortex may be involved in the development of amphetamine-induced behavioral sensitization.

成年雄性大鼠被植入慢性内侧前额叶皮质套管。2. 在连续5天的每一天，大鼠接受双侧0.5毫升前额叶皮质注射，注射物为5毫克右旋苯丙胺或生理盐水，随后皮下注射1毫克/千克右旋苯丙胺或生理盐水。3. 药物治疗后，立即将每只大鼠放入配备光电池的自发活动箱中60分钟。4. 向前额叶皮质注射右旋苯丙胺既不阻断对皮下注射右旋苯丙胺的急性运动反应，其本身也不会引起运动活动增加。然而，前额叶皮质苯丙胺治疗确实减弱了皮下苯丙胺在多次试验/数天中产生的运动致敏作用。5. 前额叶皮质中的多巴胺可能参与了苯丙胺诱导的行为致敏的发展。

Ben-Shahar O, Ettenberg A

Department of Psychology, University of California, Santa Barbara, USA.

Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):763-73. doi: 10.1016/s0278-5846(98)00038-4.

Adult male rats were implanted with chronic medial prefrontal cortex cannulae. 2. On each of 5 consecutive days, rats received bilateral 0.5 ml intra-prefrontal cortex injections of either 5 mg d-amphetamine or saline, followed by a subcutaneous injection of either 1 mg/kg d-amphetamine or saline. 3. Immediately after the drug treatments each rat was placed into a photocell equipped locomotor activity chamber for 60 min. 4. Administration of d-amphetamine into the prefrontal cortex did not block the acute locomotor response to subcutaneous d-amphetamine nor did it in itself produce an increase in locomotor activity. However, prefrontal cortex amphetamine treatments did attenuate the sensitized locomotor effects of subcutaneous amphetamine that developed over trials/days. 5. Dopamine in the prefrontal cortex may be involved in the development of amphetamine-induced behavioral sensitization.

成年雄性大鼠被植入慢性内侧前额叶皮质套管。2. 在连续5天的每一天，大鼠接受双侧0.5毫升前额叶皮质注射，注射物为5毫克右旋苯丙胺或生理盐水，随后皮下注射1毫克/千克右旋苯丙胺或生理盐水。3. 药物治疗后，立即将每只大鼠放入配备光电池的自发活动箱中60分钟。4. 向前额叶皮质注射右旋苯丙胺既不阻断对皮下注射右旋苯丙胺的急性运动反应，其本身也不会引起运动活动增加。然而，前额叶皮质苯丙胺治疗确实减弱了皮下苯丙胺在多次试验/数天中产生的运动致敏作用。5. 前额叶皮质中的多巴胺可能参与了苯丙胺诱导的行为致敏的发展。