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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Navarro J F, Pedraza C, Martín M, Manzaneque J M, Dávila G, Maldonado E

Facultad de Psicología, Universidad de Málaga, Spain.

Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):835-44. doi: 10.1016/s0278-5846(98)00043-8.

The effect of administration of gammahydroxybutyrate (GHB) and tiapride, either alone or in combination, on catalepsy behavior was examined in male mice. 2. Catalepsy was measured by bar and grid tests. Two successive evaluations were carried out 30 and 60 min after injections. 3. Tiapride (175 and 200 mg/kg) and gammahydroxybutyrate (200 mg/kg) provoked an increase of catalepsy scores, exhibiting different time courses. GHB produced a marked but short lasting catalepsy with a peak of action at 30 min, while tiapride produced a catalepsy state with a peak of action at 60 min. 4. Tiapride-induced catalepsy was potentiated by gammahydroxybutyrate administration at 30 min (bar test) and 60 min (bar and grid tests). 5. These results underlie the view that GHB interacts with central dopamine D2 transmission.

在雄性小鼠中研究了单独或联合给予γ-羟基丁酸（GHB）和硫必利对僵住行为的影响。2. 通过棒和网格试验测量僵住。注射后30分钟和60分钟进行两次连续评估。3. 硫必利（175和200mg/kg）和γ-羟基丁酸（200mg/kg）引起僵住评分增加，表现出不同的时间进程。GHB产生明显但持续时间短的僵住，作用高峰在30分钟，而硫必利产生僵住状态，作用高峰在60分钟。4. 在30分钟（棒试验）和60分钟（棒和网格试验）给予γ-羟基丁酸可增强硫必利诱导的僵住。5. 这些结果支持了GHB与中枢多巴胺D2传递相互作用的观点。

Navarro J F, Pedraza C, Martín M, Manzaneque J M, Dávila G, Maldonado E

Facultad de Psicología, Universidad de Málaga, Spain.

Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):835-44. doi: 10.1016/s0278-5846(98)00043-8.

The effect of administration of gammahydroxybutyrate (GHB) and tiapride, either alone or in combination, on catalepsy behavior was examined in male mice. 2. Catalepsy was measured by bar and grid tests. Two successive evaluations were carried out 30 and 60 min after injections. 3. Tiapride (175 and 200 mg/kg) and gammahydroxybutyrate (200 mg/kg) provoked an increase of catalepsy scores, exhibiting different time courses. GHB produced a marked but short lasting catalepsy with a peak of action at 30 min, while tiapride produced a catalepsy state with a peak of action at 60 min. 4. Tiapride-induced catalepsy was potentiated by gammahydroxybutyrate administration at 30 min (bar test) and 60 min (bar and grid tests). 5. These results underlie the view that GHB interacts with central dopamine D2 transmission.

在雄性小鼠中研究了单独或联合给予γ-羟基丁酸（GHB）和硫必利对僵住行为的影响。2. 通过棒和网格试验测量僵住。注射后30分钟和60分钟进行两次连续评估。3. 硫必利（175和200mg/kg）和γ-羟基丁酸（200mg/kg）引起僵住评分增加，表现出不同的时间进程。GHB产生明显但持续时间短的僵住，作用高峰在30分钟，而硫必利产生僵住状态，作用高峰在60分钟。4. 在30分钟（棒试验）和60分钟（棒和网格试验）给予γ-羟基丁酸可增强硫必利诱导的僵住。5. 这些结果支持了GHB与中枢多巴胺D2传递相互作用的观点。