Carey M J, Rodgers G M
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City 84132, USA.
Am J Hematol. 1998 Sep;59(1):65-73. doi: 10.1002/(sici)1096-8652(199809)59:1<65::aid-ajh13>3.0.co;2-0.
Disseminated intravascular coagulation (DIC) is a complex acquired coagulopathy resulting from excessive thrombin formation. Abnormal tissue factor (TF) expression is a major mechanism initiating DIC in many disorders, including obstetrical complications, sepsis, cancer, and trauma. Numerous laboratory tests are available to monitor DIC, but most patients are adequately managed using only routine hemostasis screening tests, and assays for fibrinogen and D-dimer. Treatment of DIC should focus on reversing the underlying disorder initiating the coagulopathy. Novel treatments are being investigated for treating DIC; many of these experimental modalities target the excessive TF activity that characterizes DIC.
弥散性血管内凝血（DIC）是一种由于凝血酶过度生成导致的复杂获得性凝血病。异常组织因子（TF）表达是许多疾病（包括产科并发症、败血症、癌症和创伤）引发DIC的主要机制。有许多实验室检查可用于监测DIC，但大多数患者仅通过常规止血筛查试验以及纤维蛋白原和D - 二聚体检测就能得到充分管理。DIC的治疗应着重于逆转引发凝血病的潜在疾病。目前正在研究用于治疗DIC的新疗法；其中许多实验性方法针对的是DIC所特有的TF过度活性。
