Markovic S N, Phyliky R L, Li C Y
Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Am J Hematol. 1998 Sep;59(1):74-8. doi: 10.1002/(sici)1096-8652(199809)59:1<74::aid-ajh14>3.0.co;2-1.
Bone marrow necrosis is a rare clinical condition often associated with hematological malignancy. The mechanism by which malignant disease causes marrow necrosis is unknown. We present a case of a patient with newly diagnosed pancytopenia with bone marrow biopsy evidence of extensive marrow necrosis. Upon further work-up utilizing Tc bone scan directed bone marrow biopsy, a massive CD8+ T cell marrow infiltrate was discovered engulfing AML-M2 blasts. The role of Tc bone scans in the work-up of bone marrow necrosis as well as the potential mechanism of AML-M2 induced marrow necrosis in the setting of reactive CD8+ T cell infiltration is discussed.
