Douay X, Lucas C, Caron C, Goudemand J, Leys D
Department of Neurology, University of Lille, France.
Acta Neurol Scand. 1998 Aug;98(2):124-7. doi: 10.1111/j.1600-0404.1998.tb01731.x.
The aim of our study was to evaluate the prevalence of antithrombin, protein C and protein S deficiencies in consecutive ischemic stroke patients under 45.
We studied 127 consecutive patients with a mean age of 34.4 years admitted for an ischemic stroke, over a 2-year period, after exclusion of those with arterial dissection. Antithrombin, protein C and protein S levels were measured in all patients at the acute stage of the ischemic stroke and measurements were repeated in case of abnormality.
We found abnormal levels in 9 patients. Seven had an acquired cause of deficiency (pregnancy, oestrogen, acute inflammation). Two had no obvious acquired cause of deficiency but further controls were normal.
Hereditary deficiencies of coagulation inhibitors are rare in ischemic stroke patients under 45 and their systematic detection seems to be of poor interest.
我们研究的目的是评估45岁以下连续性缺血性卒中患者中抗凝血酶、蛋白C和蛋白S缺乏症的患病率。
在排除动脉夹层患者后，我们在2年的时间里研究了127例连续性缺血性卒中患者，这些患者的平均年龄为34.4岁。在缺血性卒中急性期对所有患者测定抗凝血酶、蛋白C和蛋白S水平，如有异常则重复测定。
我们发现9例患者水平异常。7例有获得性缺乏原因（妊娠、雌激素、急性炎症）。2例无明显获得性缺乏原因，但进一步检查结果正常。
45岁以下缺血性卒中患者中遗传性凝血抑制剂缺乏症罕见，对其进行系统检测似乎意义不大。
