Department of Endocrinology and Metabolism, Faculty of Medicine, Yuzuncu Yil University, 65040, Van, Turkey.
Department of Internal Medicine, Faculty of Medicine, Yuzuncu Yil University, 65040, Van, Turkey.
Sci Rep. 2020 Nov 5;10(1):19208. doi: 10.1038/s41598-020-76167-2.
Parathyroid adenoma is responsible for 80-85% of cases of primary hyperparathyroidism. Increased fibrinogen levels in patients with adenoma may increase the risk of atherosclerosis and cardiovascular events. The aim of this study was to investigate the relationship between coagulation parameters and parathyroid adenoma. A prospective study included 28 female patients with parathyroid adenoma aged 40-88 years and 27 age-matched healthy controls. The coagulation parameters were assessed for each participant. The mean ages of the patient and control groups were 57.7 ± 10.9 and 53.3 ± 9.31 years, respectively. The mean level of protein S activity was 65.79 ± 13.78 in the patient group and 77.00 ± 15.72 in the control group, and the difference was statistically significant (p = 0.013). The mean fibrinogen levels of the patient and control groups were 338.78 ± 63.87 mg/dL and 304.30 ± 45.67 mg/dL, respectively, and a significant difference was found (p = 0.041). However, no significant difference was evident between the two groups with regard to the D-dimer (p = 0.238), aPTT (p = 0.645), INR (p = 0.406), protein C (p = 0.076), and AT-III (p = 0.180) levels. A positive correlation was observed between adenoma volume and fibrinogen in the patient group (r = 0.711, p = 0.001). The protein S levels were lower and the fibrinogen levels higher in the patients with parathyroid adenoma.
甲状旁腺腺瘤是导致原发性甲状旁腺功能亢进症的 80-85%的原因。腺瘤患者的纤维蛋白原水平升高可能会增加动脉粥样硬化和心血管事件的风险。本研究旨在探讨凝血参数与甲状旁腺腺瘤之间的关系。一项前瞻性研究纳入了 28 名年龄在 40-88 岁的女性甲状旁腺腺瘤患者和 27 名年龄匹配的健康对照者。对每位参与者的凝血参数进行了评估。患者组和对照组的平均年龄分别为 57.7±10.9 岁和 53.3±9.31 岁。患者组蛋白 S 活性的平均水平为 65.79±13.78，对照组为 77.00±15.72，差异具有统计学意义（p=0.013）。患者组和对照组的纤维蛋白原平均水平分别为 338.78±63.87mg/dL 和 304.30±45.67mg/dL，差异具有统计学意义（p=0.041）。然而，两组的 D-二聚体（p=0.238）、aPTT（p=0.645）、INR（p=0.406）、蛋白 C（p=0.076）和 AT-III（p=0.180）水平均无明显差异。患者组中，腺瘤体积与纤维蛋白原之间呈正相关（r=0.711，p=0.001）。患有甲状旁腺腺瘤的患者的蛋白 S 水平较低，纤维蛋白原水平较高。
