Division of Endocrinology Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Florida, USA.
Obesity (Silver Spring). 2013 Sep;21(9):E415-20. doi: 10.1002/oby.20338.
To investigate how long-term treatment with dexamethasone affects energy expenditure and adiposity in mice and whether this is influenced by feeding on a high-fat diet (HFD).
Mice were placed on a HFD for 2 weeks and started on dexamethasone at 5 mg/kg every other day during the next 7 weeks.
Treatment with dexamethasone increased body fat, an effect that was more pronounced in the animals kept on HFD; dexamethasone treatment also worsened liver steatosis caused by the HFD. At the same time, treatment with dexamethasone lowered the respiratory quotient in chow-fed animals and slowed nightly metabolic rate in the animals kept on HFD. In addition, the acute VO2 acceleration in response to β3 adrenergic-stimulation was significantly limited in the dexamethasone-treated animals, as a result of marked decrease in UCP-1 mRNA observed in the brown adipose tissue of these animals.
Long-term treatment with dexamethasone in a mouse model of diet-induced obesity decreases brown adipose tissue thermogenesis and exaggerates adiposity and liver steatosis. © 2013 American Institute of Chemical Engineers AIChE J, 2013.
研究长期使用地塞米松对小鼠能量消耗和肥胖的影响，以及这是否受高脂饮食（HFD）喂养的影响。
将小鼠置于 HFD 中 2 周，然后在接下来的 7 周内每隔一天用 5mg/kg 的地塞米松进行治疗。
地塞米松治疗会增加体脂肪，这一效果在 HFD 喂养的动物中更为明显；地塞米松治疗还加重了 HFD 引起的肝脂肪变性。与此同时，地塞米松治疗降低了 HFD 喂养动物的呼吸商，并减缓了这些动物夜间的代谢率。此外，由于观察到这些动物的棕色脂肪组织中 UCP-1mRNA 的显著减少，β3 肾上腺素能刺激引起的急性 VO2 加速明显受到限制。
在饮食诱导肥胖的小鼠模型中，长期使用地塞米松治疗会降低棕色脂肪组织的产热作用，并加剧肥胖和肝脂肪变性。©2013 美国化学工程师学会。
