Gismondo M R, Drago L, Fassina M C, Vaghi I, Abbiati R, Grossi E
Clinical Microbiology Lab, L. Sacco Teaching Hospital, University of Milan, Italy.
Dig Dis Sci. 1998 Aug;43(8):1752-4. doi: 10.1023/a:1018883603429.
Glutamine represents the principal metabolic substrate for all rapidly proliferating cells. Since part of the glutamine efficacy could be related to immunoregulating properties, we assessed the effects of orally administered glutamine on serum interleukin-2 (IL-2) levels and intestinal T-cell populations in 48 athymic (nude) mice. Twenty-four mice received a standard diet enriched by glutamine (added to drinking water at a 4% concentration), while the other 24 served as the control group and received the same diet without glutamine. In glutamine-fed animals, we observed a marked increase in IL-2 concentrations after 10 days of treatment in comparison with control group and a modest but significant increase in intestinal T-cell counts. These results suggest that oral glutamine is able to exert local and systemic immunostimulating activity that could be of relevance in the prevention of gut integrity and immune defense loss associated, for example, with trauma, surgery, and starvation.
谷氨酰胺是所有快速增殖细胞的主要代谢底物。由于谷氨酰胺功效的一部分可能与免疫调节特性有关，我们评估了口服谷氨酰胺对48只无胸腺（裸）小鼠血清白细胞介素-2（IL-2）水平和肠道T细胞群体的影响。24只小鼠接受添加了谷氨酰胺的标准饮食（以4%的浓度添加到饮用水中），而另外24只作为对照组，接受不含谷氨酰胺的相同饮食。在喂食谷氨酰胺的动物中，与对照组相比，治疗10天后我们观察到IL-2浓度显著增加，肠道T细胞计数有适度但显著的增加。这些结果表明，口服谷氨酰胺能够发挥局部和全身免疫刺激活性，这可能与预防例如与创伤、手术和饥饿相关的肠道完整性丧失和免疫防御受损有关。
