Stichel C C, Müller H W
Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine University, Moorenstrasse 5, D-40225 Düsseldorf, Germany.
Cell Tissue Res. 1998 Oct;294(1):1-9. doi: 10.1007/s004410051151.
Scar formation represents a reaction of nervous tissue to any form of physical injury. Research over the past decade has demonstrated that the scar composed of glial cells and several extracellular matrix molecules constitutes an obstacle to axon regeneration in the CNS. This review briefly summarizes the current knowledge on (a) the structural and functional features of the lesion scar and (b) the development of therapeutic interventions to override this regeneration barrier.
瘢痕形成代表了神经组织对任何形式物理损伤的一种反应。过去十年的研究表明，由神经胶质细胞和几种细胞外基质分子组成的瘢痕构成了中枢神经系统轴突再生的障碍。这篇综述简要总结了目前关于（a）损伤瘢痕的结构和功能特征，以及（b）克服这种再生障碍的治疗干预措施进展的相关知识。
