Stuurman N, Heins S, Aebi U
M. E. Müller-Institute for Microscopy at the Biozentrum, University of Basel, Basel, CH-4056, Switzerland.
J Struct Biol. 1998;122(1-2):42-66. doi: 10.1006/jsbi.1998.3987.
Nuclear lamins are intermediate filament-type proteins that are the major building blocks of the nuclear lamina, a fibrous proteinaceous meshwork underlying the inner nuclear membrane. Lamins can also be localized in the nuclear interior, in a diffuse or spotted pattern. Nuclei assembled in vitro in the absence of lamins are fragile, indicating that lamins mechanically stabilize the cell nucleus. Available evidence also indicates a role for lamins in DNA replication, chromatin organization, spatial arrangement of nuclear pore complexes, nuclear growth, and anchorage of nuclear envelope proteins. In this review we summarize the current state of knowledge on the structure, assembly, and possible functional roles of nuclear lamins, emphasizing the information concerning the ability of nuclear lamins to self-assemble into distinct oligomers and polymers.
核纤层蛋白是中间丝类型的蛋白质，是核纤层的主要组成部分，核纤层是位于内核膜下方的纤维状蛋白质网络。核纤层蛋白也可以以弥散或斑点状模式定位于细胞核内部。在没有核纤层蛋白的情况下体外组装的细胞核很脆弱，这表明核纤层蛋白在机械上稳定了细胞核。现有证据还表明核纤层蛋白在DNA复制、染色质组织、核孔复合体的空间排列、细胞核生长以及核膜蛋白的锚定中发挥作用。在这篇综述中，我们总结了目前关于核纤层蛋白的结构、组装和可能的功能作用的知识状态，重点强调了有关核纤层蛋白自组装成不同寡聚体和聚合物能力的信息。
