The central questions in pain perception may be peripheral.
作者信息
Pasternak G W
机构信息
The Cotzias Laboratory of Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10354-5. doi: 10.1073/pnas.95.18.10354.
Abstract
摘要
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Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10354-5. doi: 10.1073/pnas.95.18.10354.
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Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice.孤啡肽通过从小鼠外周神经末梢释放P物质诱导伤害性反应。
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Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.缺乏P物质受体的小鼠的伤害感受、镇痛及攻击行为改变
Nature. 1998 Mar 26;392(6674):394-7. doi: 10.1038/32904.
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Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.通过损毁表达P物质受体的脊髓I层神经元来抑制痛觉过敏。
Science. 1997 Oct 10;278(5336):275-9. doi: 10.1126/science.278.5336.275.
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The orphan opioid receptor and its endogenous ligand--nociceptin/orphanin FQ.孤儿阿片受体及其内源性配体——孤啡肽/痛敏肽。
Trends Pharmacol Sci. 1997 Aug;18(8):293-300.
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Spinal analgesic activity of orphanin FQ/nociceptin and its fragments.孤啡肽/痛敏肽及其片段的脊髓镇痛活性。
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Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat.孤啡肽对吗啡诱导镇痛的双向调节作用：在大鼠脑内起拮抗作用而在脊髓中起增强作用。
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