The central questions in pain perception may be peripheral.
作者信息
Pasternak G W
机构信息
The Cotzias Laboratory of Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10354-5. doi: 10.1073/pnas.95.18.10354.
Abstract
摘要
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The central questions in pain perception may be peripheral.疼痛感知中的核心问题可能存在于外周。
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10354-5. doi: 10.1073/pnas.95.18.10354.
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本文引用的文献
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Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice.孤啡肽通过从小鼠外周神经末梢释放P物质诱导伤害性反应。
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10949-53. doi: 10.1073/pnas.95.18.10949.
2
Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.缺乏P物质受体的小鼠的伤害感受、镇痛及攻击行为改变
Nature. 1998 Mar 26;392(6674):394-7. doi: 10.1038/32904.
3
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.通过损毁表达P物质受体的脊髓I层神经元来抑制痛觉过敏。
Science. 1997 Oct 10;278(5336):275-9. doi: 10.1126/science.278.5336.275.
4
The orphan opioid receptor and its endogenous ligand--nociceptin/orphanin FQ.孤儿阿片受体及其内源性配体——孤啡肽/痛敏肽。
Trends Pharmacol Sci. 1997 Aug;18(8):293-300.
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Pharmacological characterization of orphanin FQ/nociceptin and its fragments.孤啡肽/痛敏肽及其片段的药理学特性
J Pharmacol Exp Ther. 1997 Aug;282(2):858-65.
6
Spinal analgesic activity of orphanin FQ/nociceptin and its fragments.孤啡肽/痛敏肽及其片段的脊髓镇痛活性。
Neurosci Lett. 1997 Feb 21;223(2):113-6. doi: 10.1016/s0304-3940(97)13414-0.
7
Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat.孤啡肽对吗啡诱导镇痛的双向调节作用：在大鼠脑内起拮抗作用而在脊髓中起增强作用。
Br J Pharmacol. 1997 Feb;120(4):676-80. doi: 10.1038/sj.bjp.0700942.
8
Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide.孤啡肽作为一种作用于脊髓以上水平而非脊髓水平的抗阿片肽。
Neuroreport. 1996 Sep 2;7(13):2125-9. doi: 10.1097/00001756-199609020-00012.
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Nociceptin or antinociceptin: potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat.痛敏肽或抗痛敏肽：孤啡肽/痛敏肽在大鼠脊髓中的强效抗伤害感受作用
Neuroreport. 1996 Sep 2;7(13):2092-4.
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Peripheral morphine analgesia: synergy with central sites and a target of morphine tolerance.外周吗啡镇痛：与中枢部位的协同作用及吗啡耐受的一个靶点。
J Pharmacol Exp Ther. 1996 Nov;279(2):502-6.
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