Payne D N, Gibson S A, Lewis R
Dept. Microbiology, Reckitt & Colman Products Ltd, Hull, UK.
J R Soc Health. 1998 Feb;118(1):18-22. doi: 10.1177/146642409811800105.
The aim of this study was to ascertain the activity of a selection of widely-used antiseptic/disinfectant agents against antibiotic resistant bacteria and strains isolated from patients infected with clinically significant species. Four antiseptic agents (Dettol, Dettol Hospital Concentrate, Savlon and Betadine) were tested against Staphylococcus aureus, Methicillin Resistant S. aureus (MRSA), Enterococcus hirae, Vancomicin Resistant Enterococcus sp (VRE), Escherichia coli and E. coli 0157. The antiseptics were applied at recommended use dilutions and at a half and a quarter of those concentrations in a standard suspension test (EST). Organic material was added to mimic the presence of blood, protein and other such contaminants to be found in the clinical situation. All antiseptics tested were effective against both the antibiotic sensitive and antibiotic resistant strains of S. aureus and E. hirae as well as normal and clinical strains of E. coli at recommended concentrations. All but Betadine were also effective against the antibiotic resistant bacteria at a half and a quarter of normal concentration. The iodine containing antiseptic, however, failed the test against MRSA at a half normal concentration and showed virtually no activity against MRSA at a quarter normal concentration.
本研究的目的是确定一系列广泛使用的抗菌/消毒剂对耐药菌以及从感染具有临床意义菌种的患者中分离出的菌株的活性。针对金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌（MRSA）、海氏肠球菌、耐万古霉素肠球菌（VRE）、大肠杆菌和大肠杆菌O157测试了四种抗菌剂（滴露、滴露医院浓缩液、舒肤佳和碘伏）。在标准悬液试验（EST）中，按照推荐使用稀释度以及这些浓度的一半和四分之一应用这些抗菌剂。添加有机物质以模拟临床情况下血液、蛋白质和其他此类污染物的存在。所有测试的抗菌剂在推荐浓度下对金黄色葡萄球菌和海氏肠球菌的抗生素敏感和耐药菌株以及大肠杆菌的正常菌株和临床菌株均有效。除碘伏外，所有抗菌剂在正常浓度的一半和四分之一时对耐药菌也有效。然而，含碘抗菌剂在正常浓度一半时对MRSA的测试未通过，在正常浓度四分之一时对MRSA几乎没有活性。
