Gauvin D V, Vanecek S A, Baird T J, Briscoe R J, Vallett M, Carl K L, Wasielewski J A, Holloway F A
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190-3000, USA.
Exp Clin Psychopharmacol. 1998 Aug;6(3):264-73. doi: 10.1037//1064-1297.6.3.264.
Sprague-Dawley (Rattus norvegicus) rats were trained in a drug discrimination task using the state-dependent interoceptive stimulus attributes of cocaine's delayed or rebound effects (CDE) versus "normal" basal homeostasis. Rats were injected with either 32 mg/kg cocaine or equivalent volumes of saline (SAL), subcutaneously, 13 hr before the sessions. Rats demonstrated > 90% discriminative accuracy. Test sessions showed a time-dependent acute cocaine isodirectional rebound state that engendered a shift from predominantly SAL- to CDE-appropriate responding approximately 7 hr after the high training dose injection and lasted for approximately 10 hr (17 hr postinjection). The delayed or rebound state was dose dependent and engendered only a biphasic partial generalization with acute cocaine injections. There were no detectable levels of cocaine or any of its behaviorally active metabolites at the 13-hr postinjection interval. Tests conducted with various doses of lidocaine, chlordiazepoxide, N-methyl-d-aspartic acid, ketamine, and buspirone engendered SAL- or default-appropriate responding. The anxiogenic drug, pentylenetetrazole, produced partial generalization to the cocaine rebound cue.
斯普拉格-道利（褐家鼠）大鼠在药物辨别任务中接受训练，利用可卡因延迟或反弹效应（CDE）与“正常”基础内环境稳定状态相关的内感受性刺激属性。在实验前13小时，大鼠皮下注射32mg/kg可卡因或等量的生理盐水（SAL）。大鼠表现出>90%的辨别准确率。测试环节显示出一种时间依赖性的急性可卡因同向性反弹状态，在高训练剂量注射后约7小时，这种状态导致反应从主要对SAL适当转变为对CDE适当，并持续约10小时（注射后17小时）。延迟或反弹状态是剂量依赖性的，并且仅与急性可卡因注射产生双相部分泛化。在注射后13小时的间隔时间内，未检测到可卡因或其任何具有行为活性的代谢物水平。用不同剂量的利多卡因、氯氮卓、N-甲基-D-天冬氨酸、氯胺酮和丁螺环酮进行的测试产生了对SAL或默认适当的反应。致焦虑药物戊四氮对可卡因反弹线索产生了部分泛化。
