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比例因子法在估算由平面界面分隔的不同介质的β剂量分布中的应用。

Application of the scaling factor method to estimation of beta dose distributions for dissimilar media separated by a planar interface.

作者信息

Marcu S M, Prestwich W V

机构信息

Department of Physics and Astronomy, McMaster University, Hamilton, Ontario, Canada.

出版信息

Med Phys. 1998 Aug;25(8):1478-86. doi: 10.1118/1.598322.

DOI:10.1118/1.598322
PMID:9725137
Abstract

The most accurate method of calculating beta dose distribution currently relies on the Monte Carlo technique. The major drawback of the method is the long computing time required to follow a large number of "electron histories" in order to achieve good statistics, which makes the method unattractive for practical radiation therapy. A way to avoid the Monte Carlo calculations for homogeneous media was suggested by Cross and co-workers (AECL Report Nos. 7617, 1982; 10521, 1992), and is known as the "scaling factor" method. It consists of the determination of the depth dose distribution in a medium based on known data about the dose distribution in an arbitrary reference medium (e.g., air, water) by the use of a scaling factor on distance and a closely related renormalization factor imposed by energy conservation. This work is an attempt to extend the applicability of the scaling factor method to dissimilar media to a planar interface. The investigation was done for an isotropic source of the radioisotope 32P and an interface between water and medium "i," where medium "i" could be any medium with atomic number in the range 8 < Z < 50. The method was checked using three randomly chosen elements 40Zr, 32Ge, and 26Fe, each forming planar interfaces with water at either 100 or 350 mg/cm2. Discrepancies of less than 5% were detected (acceptable for practical radiotherapy) for the depth within which at least 95% of the initial energy is deposited.

摘要

目前计算β剂量分布最准确的方法依赖于蒙特卡罗技术。该方法的主要缺点是为了获得良好的统计结果,需要跟踪大量“电子历史”,这使得计算时间很长,从而使该方法对于实际放射治疗缺乏吸引力。克罗斯及其同事(加拿大原子能公司报告编号分别为7617,1982年;10521,1992年)提出了一种避免对均匀介质进行蒙特卡罗计算的方法,即所谓的“比例因子”法。它包括根据关于任意参考介质(如空气、水)中剂量分布的已知数据,通过使用距离比例因子和由能量守恒施加的密切相关的重整化因子,来确定介质中的深度剂量分布。这项工作试图将比例因子法的适用性扩展到不同介质的平面界面。针对放射性同位素32P的各向同性源以及水与介质“i”之间的界面进行了研究,其中介质“i”可以是原子序数在8<Z<50范围内的任何介质。使用三种随机选择的元素40Zr、32Ge和26Fe对该方法进行了检验,它们分别在100或350mg/cm2的情况下与水形成平面界面。对于至少95%的初始能量沉积的深度,检测到的差异小于5%(对于实际放射治疗来说是可接受的)。

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