Oyen W J, Claessens R A, van Horn J R, van der Meer J W, Corstens F H
University Hospital Nijmegen, Department of Nuclear Medicine, The Netherlands.
J Nucl Med. 1990 Apr;31(4):403-12.
The utility of indium-111-(111In) labeled immunoglobulin G (IgG) to detect infection of bone and adjacent tissues was investigated. Proof of infection was obtained by cultures taken at surgery. All 32 patients showed focally increased uptake on the technetium-99m- (99mTc) methylene diphosphonate (MDP) skeletal scintigraphies. Labeled immunoglobulin correctly identified presence, location, extent and soft-tissue involvement of the suspected inflammatory site. In these patients, focally increasing accumulation was noted over 48 hr. Discrimination between infection and sterile inflammatory lesions was not possible. Two fractures, 6-mo-old, and an aseptic loosening of a total-hip prosthesis were not visualized. Side effects after the immunoglobulin administration were not observed. Radiolabeled immunoglobulin is a new and safe radiopharmaceutical for the investigation of infectious bone and joint disease. The sensitivity of this agent appears at least as high as that of labeled leukocytes. However, labeled immunoglobulin can easily be prepared in every nuclear medicine department.
研究了铟 - 111（¹¹¹In）标记的免疫球蛋白G（IgG）在检测骨及相邻组织感染方面的效用。通过手术时采集的培养物获得感染证据。所有32例患者在锝 - 99m（⁹⁹ᵐTc）亚甲基二膦酸盐（MDP）骨闪烁显像上均显示局部摄取增加。标记的免疫球蛋白能正确识别可疑炎症部位的存在、位置、范围及软组织受累情况。在这些患者中，48小时内可见局部积聚增加。无法区分感染性病变和无菌性炎症病变。两处6个月大的骨折及全髋关节假体无菌性松动未显影。未观察到免疫球蛋白给药后的副作用。放射性标记的免疫球蛋白是一种用于研究感染性骨和关节疾病的新型安全放射性药物。该制剂的敏感性似乎至少与标记白细胞的敏感性一样高。然而，标记免疫球蛋白在每个核医学科室都能轻松制备。
